Nucleic Acid Regulatory Elements for Liver Gene Expression
Summary
USPTO published patent application US20260109979A1 for nucleic acid regulatory elements (NAREs) that enhance gene expression in liver tissue. The application covers expression cassettes and vectors containing these elements for gene therapy applications, filed October 11, 2023 under application number 19117793. Named inventors include Alexandria Forbes, Josefa Sullivan, Chenjin Jin, Enrico Mossotto, Matthew During, Ce Feng Liu, Dustin Lee, and Jessica Schmerler.
“The application relates to nucleic acid regulatory elements (NAREs) that are able to enhance expression of genes in the liver.”
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 264 changes logged to date.
What changed
USPTO published a patent application disclosing nucleic acid regulatory elements (NAREs) capable of enhancing expression of genes in the liver. The application covers methods employing NAREs, expression cassettes, and vectors for gene therapy applications.
For biotechnology and pharmaceutical companies developing gene therapies, this patent application indicates a new approach to liver-specific gene expression that may affect freedom-to-operate analyses. Competitors in hepatocyte-based therapies should review the claims when the application proceeds to grant.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
NUCLEIC ACID REGULATORY ELEMENTS FOR GENE EXPRESSION IN THE LIVER AND METHODS OF USE
Application US20260109979A1 Kind: A1 Apr 23, 2026
Inventors
Alexandria Forbes, Josefa Sullivan, Chenjin Jin, Enrico Mossotto, Matthew During, Ce Feng Liu, Dustin Lee, Jessica Schmerler
Abstract
The application relates to nucleic acid regulatory elements (NAREs) that are able to enhance expression of genes in the liver. The application further relates to methods employing NAREs and uses of the NAREs. Expression cassettes and vectors containing NAREs are also disclosed. These are particularly useful for applications using gene therapy.
CPC Classifications
C12N 15/113 A61K 31/7088 A61K 48/005 A61P 25/28 C12N 5/067 C12N 15/8645 C12N 2750/14132 C12N 2750/14143 C12N 2830/008 C12N 2830/50
Filing Date
2023-10-11
Application No.
19117793
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