Partial Ciliary Block Risk Study After Cataract Surgery
ClinicalTrials.gov Studies
Summary
A prospective observational study (NCT07549438) will examine risk factors for developing classic or partial ciliary block following combined cataract surgery and goniosynechialysis in patients with primary angle-closure disease. Researchers will use non-invasive imaging modalities including ultrasound biomicroscopy and optical coherence tomography to measure anterior chamber width, lens thickness, and axial length before surgery, excluding patients with eye length under 19mm. Participants will undergo standard surgery and be monitored for 12 months during routine follow-up visits.
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What changed
The study registered on ClinicalTrials.gov describes a prospective, observational investigation examining risk predictors for ciliary block and aqueous misdirection following combined cataract extraction with goniosynechialysis in primary angle-closure disease patients. Researchers will employ standard imaging tools—ultrasound biomicroscopy and optical coherence tomography—to obtain detailed pre-surgical measurements of anterior segment structures. Patients with highly short axial length below 19mm are excluded from participation. As an observational study, participants will receive their scheduled standard-of-care surgery and be followed for 12 months.
For clinical investigators, ophthalmic surgeons, and healthcare facilities treating primary angle-closure glaucoma, this study may inform future pre-surgical risk stratification protocols. The exclusion criterion of axial length below 19mm reflects existing clinical awareness that very short eyes carry disproportionate risk. Institutions conducting similar angle-closure surgeries should monitor for emerging findings that could influence informed consent discussions or surgical planning.
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Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Predicting the Risk of Partial Ciliary Block After Cataract and Goniosynechialysis Surgery in Primary Angle-Closure Disease
Observational NCT07549438 Kind: OBSERVATIONAL Apr 24, 2026
Abstract
Primary angle-closure disease (PACD) is a major cause of vision loss, often treated with a combined surgery that removes the eye's natural lens (cataract surgery) and physically opens the eye's drainage system (goniosynechialysis). While effective, this surgery carries a small risk of a severe complication called ciliary block (or aqueous misdirection), where fluid builds up in the wrong part of the eye, pushing structures forward and causing high eye pressure. Recently, doctors have also noticed a "partial" form of this block, which can slowly cause the eye's drainage angle to close again without immediate severe symptoms.
The purpose of this prospective, observational study is to identify which patients are at the highest risk for developing classic or partial ciliary block after this combined surgery. Researchers will use standard, non-invasive eye imaging tools-such as ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT)-to take highly detailed measurements of the front of the eye before surgery. They will specifically look at factors like the width of the anterior chamber, the thickness of the lens, and the eye's overall length. To ensure accuracy, patients with a very short eye length (less than 19mm) will not be included in the study.
Because this is an observational study, participation will not change a patient's standard surgical plan. Patients will undergo their scheduled surgery and be monitored for 12 months during routine follow-up visits t...
Conditions: Primary Angle-Closure Glaucoma
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