oXiris Hemofilter in Septic Shock With AKI Trial
Summary
NIH registered a multicenter retrospective observational study (NCT07539883) evaluating the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury requiring continuous renal replacement therapy. The study uses a Target Trial Emulation approach to compare patients treated with oXiris® filters against standard CRRT filters, examining in-hospital mortality, fluid balance, and vasopressor requirements. The study addresses inconsistent evidence regarding whether oXiris® improves survival through endotoxin and cytokine removal.
What changed
NIH registered a new observational clinical trial (NCT07539883) on ClinicalTrials.gov describing a multicenter retrospective cohort study of the oXiris® hemofilter in septic shock patients with acute kidney injury. The study will use Target Trial Emulation methodology to compare outcomes between oXiris® filter patients and standard CRRT filter patients, focusing on in-hospital mortality, fluid balance, and vasopressor requirements. This is a registry entry documenting planned research and does not establish any regulatory requirements or compliance obligations. Healthcare institutions and researchers conducting or reviewing continuous renal replacement therapy studies may reference this trial design when evaluating similar evaluation approaches for extracorporeal cytokine removal devices.
Archived snapshot
Apr 20, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
Observational NCT07539883 Kind: OBSERVATIONAL Apr 20, 2026
Abstract
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.
Conditions: Septic Shock, Multiorgan Failure, Sepsis
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