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Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients (NCT07542093)

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Summary

The NIH ClinicalTrials.gov registry has posted a new prospective observational study (NCT07542093) evaluating Bedside Lung Ultrasound (LUS) as a monitoring tool for lung recruitment maneuvers in mechanically ventilated adult patients with morbid obesity (BMI ≥ 33 kg/m²) in the ICU. The study will use a standardized 12-zone ultrasound scan to calculate a Total Lung Ultrasound Score and identify optimal PEEP settings. Conditions studied include morbid obesity, respiratory failure, atelectasis, and ventilator-induced lung injury.

“This prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time.”

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What changed

The NIH ClinicalTrials.gov registry has recorded a new prospective observational study examining the use of Bedside Lung Ultrasound (LUS) to monitor lung recruitment maneuvers in ICU patients with morbid obesity requiring mechanical ventilation. The study targets adult patients with BMI ≥ 33 kg/m² and will use a 12-zone ultrasound scan protocol before, during, and after step-by-step lung recruitment maneuvers to calculate a Total Lung Ultrasound Score and determine optimal PEEP settings.

For healthcare providers and clinical investigators, this study registration indicates growing research interest in point-of-care ultrasound applications for ventilator management in obese patient populations. ICU protocols for mechanically ventilated patients with elevated BMI may be subject to future evidence-based updates as study findings emerge.

Archived snapshot

Apr 21, 2026

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Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients

Observational NCT07542093 Kind: OBSERVATIONAL Apr 21, 2026

Abstract

Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse. This happens because the extra weight of the chest and abdomen presses on the lungs, reducing their capacity and making it difficult to maintain adequate oxygen levels. To address this, doctors often perform a standard lung recruitment maneuver, which involves temporarily increasing the air pressure from the ventilator to gently pop open the collapsed lung areas. However, standard bedside monitoring tools make it difficult to see exactly how well the different regions of the lungs are reopening.

This prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time.

During the study, researchers will use a standardized 12-zone ultrasound scan to examine the lungs of mechanically ventilated adult patients (BMI ≥ 33 kg/m²) before, during, and after a step-by-step lung recruitment maneuver. By calculating a "Total Lung Ultrasound Score," the medical team can directly visualize and measure the transition from collapsed tissue to normal, aerated lung tissue. Furthermore, the ultrasound will be used during a step-down pressure phase to help identify the patient's "optimal PEEP" (Positive End-Expiratory Pressure), which is the exact customized pressure needed to keep the lungs op...

Conditions: Morbid Obesity, Obesity, Respiratory Failure, Atelectasis, Ventilator-Induced Lung Injury (VILI)

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Last updated

Classification

Agency
NIH
Published
April 21st, 2026
Instrument
Notice
Branch
Executive
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Docket
NCT07542093

Who this affects

Applies to
Healthcare providers Clinical investigators
Industry sector
6221 Hospitals & Health Systems
Activity scope
Clinical study registration Medical research ICU ventilator protocols
Threshold
BMI ≥ 33 kg/m²; mechanically ventilated adult patients
Geographic scope
United States US

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Topics
Public Health Medical Devices

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