Biofilm-induced Antimicrobial Resistance Risk Eradication in Critical Care Central Venous Catheters
Summary
NIH has registered an observational study (NCT07546994) examining biofilm-induced antimicrobial resistance on central venous catheters in critical care patients. The study will prospectively collect infected or colonized catheters from intensive care unit patients and perform microbial analysis to quantify biofilm density and describe its spatial distribution across extra- and intraluminal compartments. This registry entry documents the study protocol and does not create compliance obligations for any party.
“The main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.”
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What changed
This document registers an observational study on ClinicalTrials.gov, providing protocol details for research examining biofilm characteristics on central venous catheters in intensive care patients. The study does not involve any therapeutic intervention — it is purely observational, involving microbial analysis of catheters already removed from patients. No compliance obligations, reporting requirements, or deadlines are imposed on any party by this registry entry.
Healthcare institutions conducting catheter-related infection research may find this protocol relevant for understanding biofilm research methodologies in critical care settings. The study's focus on in vivo biofilm kinetics and spatial distribution may inform future infection prevention strategies, though the study itself does not mandate any clinical practice changes.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters
Observational NCT07546994 Kind: OBSERVATIONAL Apr 23, 2026
Abstract
Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies.
The main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.
Conditions: Catheter-Related Infections, Biofilms, Infection Prevention
Interventions: Microbial analysis of catheter biofilm
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