Novel Antibiotic Nidaromycin from New Gene Cluster
Summary
The USPTO published patent application US20260109688A1 on April 23, 2026, covering a novel antibiotic compound termed nidaromycin and its associated biosynthetic gene cluster (BGC). The application also discloses related genes, nucleic acid molecules, constructs, vectors, and host cells for producing nidaromycin, as well as methods of use. As a patent application, no enforceable rights exist yet; the invention remains subject to examination before any patent grant.
“The present invention provides a new antibiotic compound termed nidaromycin derived from a new biosynthetic gene cluster (BGC), and its uses.”
About this source
USPTO classification C07D covers heterocyclic organic compounds: the chemical core of most small-molecule drugs, including kinase inhibitors, GLP-1 receptor agonists, antibiotics, antivirals, and CNS therapies. Every newly published application in C07D lands in this feed, around 160 a month. Applications publish 18 months after filing, so this feed reveals what medicinal chemistry groups at Pfizer, Novartis, Roche, Shionogi, and others were synthesizing in the prior year and a half. Watch this if you run a medicinal chemistry program, file patent clearance for new drug candidates, scout competitor pipelines before clinical readouts, or track heterocyclic innovation across therapeutic areas.
What changed
The USPTO published patent application US20260109688A1 disclosing nidaromycin, a new antibiotic compound derived from a previously unknown biosynthetic gene cluster. The application covers the compound itself, associated genes and nucleic acid molecules encoding the biosynthetic machinery, and constructs, vectors, and host cells for expressing the BGC. CPC classifications indicate applications in C07D (heterocyclic compounds), A61K31/7036 (medicinal preparations containing antibiotics), and A61P31/04 (anti-infectives).
Affected parties include pharmaceutical companies engaged in antibiotic research and development, as well as entities pursuing novel antimicrobial therapeutics derived from biosynthetic gene clusters. While the application creates no immediate compliance obligations, it signals prior art that could affect freedom-to-operate analyses for competing antibiotic development programs. Parties with overlapping R&D activities should review the published claims once available.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
NOVEL ANTIBIOTIC COMPOUND
Application US20260109688A1 Kind: A1 Apr 23, 2026
Inventors
Alexander WENTZEL, Kristin Fløgstad DEGNES, Giang-Son NGUYEN, Geir KLINKENBERG, Håvard SLETTA, Trond Erling ELLINGSEN, Mario Dino VAN DISSEL, Gilles VAN WEZEL, Marnix MEDEMA, Antonio FERNANDEZ-GUERRA
Abstract
The present invention provides a new antibiotic compound termed nidaromycin derived from a new biosynthetic gene cluster (BGC), and its uses. Also provided herein are novel genes and nucleic acid molecules encoding the biosynthetic machinery for the production of nidaromycin, and to constructs, vectors, and host cells for expressing the BGC and methods for producing the compound.
CPC Classifications
C07D 405/14 A61K 31/7036 A61P 31/04 C12N 1/20 C12N 15/76 C12R 2001/465
Filing Date
2023-05-16
Application No.
18864850
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