Oxygen Modulator Hypoxic/Hyperoxic Tabata Training Study
Summary
NIH registered a clinical trial (NCT07551869) examining how breathing air with different oxygen concentrations during high-intensity interval training (Tabata protocol) affects aerobic capacity, ventilatory thresholds, blood lactate levels, and perceived exertion. The three-week study will enroll participants randomly assigned to breathe hyperoxic or hypoxic air during training sessions. This is a research study registry entry with no compliance obligations.
About this source
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What changed
This document registers a clinical trial on ClinicalTrials.gov describing a physiological study on oxygen modulation during high-intensity interval training. The study will assess aerobic capacity and metabolic responses to hyperoxic and hypoxic breathing conditions using the Tabata protocol. There are no compliance obligations, enforcement actions, or regulatory changes associated with this study registration. Compliance officers can note this as informational research that does not create new regulatory requirements.
Archived snapshot
Apr 28, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.
N/A NCT07551869 Kind: NA Apr 27, 2026
Abstract
The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects:
- Aerobic capacity (VO₂max)
- Ventilatory thresholds
- Blood lactate levels
- Perceived exertion This research aims to better understand how oxygen availability influences physiological adaptations to exercise.
If you agree to participate, you will undergo the following:
Baseline testing:
- Cardiopulmonary exercise test (cycling until exhaustion)
- Measurement of oxygen consumption, heart rate, and ventilatory thresholds
- Blood lactate measurement (finger prick)
Training intervention (3 weeks):
- 3 sessions per week (total of 9 sessions)
- High-intensity interval training (Tabata protocol: 8 × 20 seconds effort / 10 seconds rest)
- Exercise performed on an air-resistance cycle ergometer
During training, you will breathe either:
- Hyperoxic air (high oxygen concentration) or
- Hypoxic air (low oxygen concentration) You will be randomly assigned to one of these conditions.
Post-intervention testing:
• Same assessments as baseline
The risks associated with this study are similar to those encountered during high-intensity exercise:
- Fatigue
- Muscle soreness
- Shortness of breath
- Temporary discomfort from finger-prick blood sampling
Breathing altered oxygen concentrations (hypoxia or hyperoxia) may induce:
- Mild dizziness
- Increased breathing effort (hypoxia)
- Sensations of ease or alt...
Conditions: Hyperoxia / High FiO₂ Exposure, Interval Training, HIIT, High Intensity Interval Training, VO2max, Hypoxia
Interventions: FIO2 modulation during HIIT protocol on assault bike
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