TriLink BioTechnologies Modified RNA With 3′-Stabilizing Region
Summary
TriLink BioTechnologies, LLC has filed US Patent Application US20260109977A1 covering modified RNA molecules where a 3′-stabilizing region is covalently attached to the RNA, and where the 3′-stabilizing region comprises one or more modified nucleosides. The application (No. 19386605) was filed on November 12, 2025, and names eight inventors: Chunping Xu, Chanfeng Zhao, Paul Theodore Ludford III, Dhamodharan Venugopal, Alexandre V. Lebedev, and Hengyuan Lang. This biotechnology patent application relates to methods for increasing protein expression through modified RNA design.
“Described herein are modified RNA molecules where a 3′-stabilizing region is covalently attached to the RNA, and where the 3′-stabilizing region comprises one or more modified nucleosides.”
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GovPing monitors USPTO Patent Applications - Biotech (C12N) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 258 changes logged to date.
What changed
US Patent Application US20260109977A1 describes novel modified RNA molecules featuring a 3′-stabilizing region covalently attached to the RNA, where the 3′-stabilizing region incorporates one or more modified nucleosides. The filing also discloses methods of synthesizing said modified RNA molecules.
For parties involved in RNA therapeutics, vaccine development, or gene expression research, this patent application should be considered during freedom-to-operate analyses. Competitors developing similar 3′-stabilized RNA constructs should review the claims to assess potential overlap with their own product pipelines. The application is currently pending examination by the USPTO.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION
Application US20260109977A1 Kind: A1 Apr 23, 2026
Assignee
TriLink BioTechnologies, LLC
Inventors
Chunping Xu, Chanfeng Zhao, Paul Theodore Ludford, III, Dhamodharan Venugopal, Alexandre V. Lebedev, Hengyuan Lang
Abstract
Described herein are modified RNA molecules where a 3′-stabilizing region is covalently attached to the RNA, and where the 3′-stabilizing region comprises one or more modified nucleosides. Methods of synthesizing said RNAs are also provided herein.
CPC Classifications
C12N 15/11 A61K 31/7115 A61K 31/7125 C12N 15/10 C12N 2310/3515 C12N 2310/531
Filing Date
2025-11-12
Application No.
19386605
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