PRMT5 inhibitors for cancer treatment
Summary
USPTO granted patent US12595248B2 to Merck Sharp & Dohme LLC covering PRMT5 inhibitor compounds of Formula I and their use in treating cancer, sickle cell disease, and hereditary persistence of foetal hemoglobin (HPFH). The patent includes 32 claims covering the compound compositions, methods of making, pharmaceutical formulations, and treatment methods.
What changed
USPTO granted patent US12595248B2 to Merck Sharp & Dohme LLC for PRMT5 (protein arginine methyltransferase 5) inhibitor compounds. The patent claims 32 items covering compounds of Formula I, their pharmaceutically acceptable salts, esters, and prodrugs, along with methods of manufacturing and pharmaceutical compositions.
For pharmaceutical companies developing oncology therapeutics, this patent establishes intellectual property barriers for PRMT5 inhibitor compounds with similar structures or uses. Competitors in the cancer therapeutics space should review this patent landscape before proceeding with R&D in this area to assess freedom-to-operate implications.
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Apr 7, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
PRMT5 inhibitors
Grant US12595248B2 Kind: B2 Apr 07, 2026
Assignee
Merck Sharp & Dohme LLC
Inventors
Michelle Machacek, Michael D. Altman, Chunghui Huang, Michael H. Reutershan, David L. Sloman, Phieng Siliphaivanh, Sebastian E. Schneider, Charles S. Yeung, David J. Witter, Craig R. Gibeau, Yingchun Ye
Abstract
The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
CPC Classifications
C07D 401/00 C07D 405/00 C07D 413/00 C07D 451/00 C07D 471/00 C07D 487/00 C07D 498/00
Filing Date
2020-12-14
Application No.
17783975
Claims
32
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