Fine-tuned Physical Training to Improve Quality of Life in Older Individuals, NCT07546734
Summary
A clinical trial registration was filed on ClinicalTrials.gov (NCT07546734) for a randomized controlled study at the University of Rome Foro Italico evaluating three 8-week physical training interventions in 45 community-dwelling frail or pre-frail older adults aged 65 and above. The study compares resistance training alone, resistance-core training, and cognitive-resistance-core training to assess effects on physical function, cognitive performance, and emotional well-being.
“Forty-five frail or pre-frail community-dwelling older adults aged ≥65 years will be randomly assigned to three 8-week intervention groups: A) resistance training; B) resistance-core training; C) cognitive-resistance-core training.”
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What changed
A new clinical trial registration was published on ClinicalTrials.gov for a study assessing fine-tuned physical training interventions in older adults. Forty-five frail or pre-frail community-dwelling adults aged ≥65 years will be randomly assigned to three 8-week intervention groups: resistance training, resistance-core training, or cognitive-resistance-core training combining dual-task training with psychotherapeutic principles.
This is a study registration rather than a regulatory action; it does not impose compliance obligations on regulated entities. Healthcare researchers and institutional review boards may reference this protocol when reviewing similar intervention studies for older adult populations.
Archived snapshot
Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Fine-tuned Physical Training to Improve Quality of Life in Older Individuals
N/A NCT07546734 Kind: NA Apr 23, 2026
Abstract
The overall aim of this project, which is based upon the interdisciplinary expertise of four research groups within the University of Rome Foro Italico, in the macro-areas of psychology, bioengineering, physiology, and internal medicine, is to improve the overall health and well-being of community-dwelling frail older adults, who are often suffering from non-communicable diseases, by means of an integration of innovative cognitive and resistance-core training. Forty-five frail or pre-frail community-dwelling older adults aged ≥65 years will be randomly assigned to three 8-week intervention groups: A) resistance training; B) resistance-core training; C) cognitive-resistance-core training. Comparison between groups C and B will show the effects of an innovative cognitive-motor dual-task training method, which will incorporate principles of modern psychotherapeutic approaches to boost physical training, and to improve cognitive, emotional, and mood disturbances in older ages.
Comparison between groups B and A will focus on the motor component of the intervention, showing the effects of adding specific core-exercises to a traditional resistance training program on muscle strength, power, and the ability to safely carry out functional abilities of daily life.
As outcomes, clinical and psychological scales, cognitive tasks, and their underlying cortical mechanisms will be measured. In addition, state-of-art physiological and biomechanical methods will be used to study human ki...
Conditions: Frail Elderly, Elderly, Aging, Aging Frailty, Sarcopenia in Elderly
Interventions: Resistance Training (RT), Resistance training + CORE (RT+CORE), CMDT training
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