Resistance Exercise Snacks in Pre-frail Older Adults
ClinicalTrials.gov Studies
Summary
A four-arm randomized pilot trial (N=48-60) compares four fragmentation patterns of a three-exercise resistance snack (sit-to-stand, squat, heel raise; 15 repetitions per exercise per day) in pre-frail older adults (Fried score 1-2, aged 70+). The study will assess lower limb strength, balance, and executive function at baseline, week 4, and week 8. Results will determine the optimal fragmentation pattern and provide effect sizes for a future definitive trial.
“This four-arm randomized pilot trial (N=48-60) compares four fragmentation patterns of a three-exercise resistance snack (sit-to-stand, squat, heel raise; 15 repetitions/exercise/day) in pre-frail older adults (Fried score 1-2, ≥70 years).”
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What changed
This document registers a randomized clinical trial on ClinicalTrials.gov evaluating different patterns of resistance-based exercise snacks in pre-frail older adults. The study tests four exercise fragmentation approaches ranging from single-bout (1×15) to maximally fragmented (15×1) delivery of three resistance exercises. Participants are pre-frail adults aged 70+ with Fried score 1-2, and outcomes include lower limb strength, balance, and executive function at weeks 4 and 8.
Clinical investigators and healthcare providers involved in geriatric care or frailty prevention programs may find this trial relevant for understanding exercise prescription strategies for older adults. The study results could inform future exercise recommendations and clinical trial design for pre-frail populations.
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Apr 25, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effects of Resistance-based Exercise Snacks With Varying Fragmentation Patterns on Lower Limb Function and Executive Cognition in Pre-frail Older Adults
N/A NCT07551206 Kind: NA Apr 24, 2026
Abstract
This four-arm randomized pilot trial (N=48-60) compares four fragmentation patterns of a three-exercise resistance snack (sit-to-stand, squat, heel raise; 15 repetitions/exercise/day) in pre-frail older adults (Fried score 1-2, ≥70 years). Groups differ by repetitions/bout×bouts/day: G1=1×15, G2=3×5, G3=5×3, G4=15×1. Outcomes (lower limb strength, balance, executive function) are assessed at baseline, week 4, and week 8. The study will determine the optimal fragmentation pattern and provide effect sizes for a future definitive trial.
Conditions: Effects of Exercise on Older Adults
Interventions: Highly Fragmented Exercise Snack, Moderately Fragmented Exercise Snack, Lowly Fragmented Exercise Snack, Consecutive Exercise (Active Control)
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