DNA Triangular Origami Emulsion Preparation, Zhejiang University, Apr 21
Summary
USPTO issued patent US12605312B2 to Zhejiang University on April 21, 2026, covering a DNA triangular origami-based single and double emulsifier preparation method for drug delivery applications. The patent discloses using DNA triangular origami as an emulsifier enabling simultaneous delivery of hydrophilic arbutin and hydrophobic coumaric acid through central nano channels, achieving zero-order release via intermolecular forces and pore confinement effects. The filing date was May 24, 2022, with application number 17752477 and 8 claims.
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GovPing monitors USPTO Patent Grants - Pharma (A61K) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 22 changes logged to date.
What changed
USPTO granted patent US12605312B2 to Zhejiang University on April 21, 2026, covering a DNA triangular origami-based single and double emulsifier preparation method for drug delivery. The patent discloses DNA triangular origami structures that function as emulsifiers, with central nano holes serving as channels for controlled release of compounds including hydrophilic arbutin and hydrophobic coumaric acid, achieving zero-order release through intermolecular forces and pore confinement effects. The invention has applications in pharmaceutical and cosmetic formulations. Zhejiang University gains exclusive rights to the technology, which does not impose compliance obligations on other parties.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Preparation method and application of single emulsifier and double emulsion based on DNA triangular origami technology
Grant US12605312B2 Kind: B2 Apr 21, 2026
Assignee
Zhejiang University
Inventors
Zisheng Luo, Hao Huang, Li Li, Guangsheng Zhao, Gongnian Xiao, Xinyu Lin, Yanqun Xu
Abstract
A preparation method and application of a single emulsifier and a double emulsion based on DNA triangular origami technology include designing and synthesizing staple strands of DNA triangular origami; mixing DNA scaffold strand and staple strands to synthesize the DNA triangular origami; purifying and enriching the triangular origami; and preparing the double emulsion. A process of the disclosure is simple, the obtained DNA triangular origami can be used as a single emulsifier of the double emulsion, the prepared emulsion can deliver hydrophilic arbutin and hydrophobic coumaric acid at the same time, and a central nano hole of the DNA triangular origami can be used as a nano channel for releasing arbutin and coumaric acid. Zero-order release can be achieved through an intermolecular force between arbutin and coumaric acid and the DNA triangular origami and pore confinement effect.
CPC Classifications
A61K 8/06 A61K 8/066 A61K 8/606 C12N 2310/3515
Filing Date
2022-05-24
Application No.
17752477
Claims
8
Parties
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