CRISPR Enzymes and Systems
Summary
The USPTO published patent application US20260092266A1 by Feng Zhang et al. for engineered CRISPR-Cas systems comprising multimeric complexes with β-CASP polypeptides and small Type II-B, II-C, and II-D Cas proteins for modifying target polynucleotides. The application (No. 19388533) was filed November 13, 2025, and published April 2, 2026.
What changed
The USPTO published a patent application for engineered CRISPR-Cas gene editing systems developed by Feng Zhang, Han Altae-Tran, and Soumya Kannan. The application covers multimeric CRISPR-Cas complexes containing β-CASP polypeptides, multiple Cas polypeptides, and guide molecules, as well as small Cas proteins from Type II-B, II-C, and II-D categories, including packaging and delivery systems and methods for modifying target polynucleotides.
This is a standard patent publication providing public notice of a biotechnology invention. No compliance actions are required from other entities. Companies developing gene therapies or CRISPR-based applications should review the published claims to assess potential IP overlap with their own research programs.
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
CRISPR ENZYMES AND SYSTEMS
Application US20260092266A1 Kind: A1 Apr 02, 2026
Inventors
Feng Zhang, Han Altae-Tran, Soumya Kannan
Abstract
Described herein are engineered, non-naturally occurring systems and compositions comprising multimeric CRISPR-Cas complexes comprising a β-CASP polypeptide, a plurality of Cas polypeptides, and a guide molecule, packaging and delivery systems thereof, and methods of use thereof, for modifying target polynucleotides. In addition, described herein are engineered, non-naturally occurring systems and compositions comprising a class of small Cas proteins (Type II-B, II-C, and II-D Cas proteins) and methods of modifying target sequences using the Type II-B, II-C, II-D Cas proteins and systems thereof.
CPC Classifications
C12N 9/222 C12N 15/111 C12N 15/8203 C12N 15/86 C12N 15/902 C07K 2319/09 C12N 2310/20
Filing Date
2025-11-13
Application No.
19388533
Named provisions
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