PENS vs TENS for Hand Function in Multiple Sclerosis
ClinicalTrials.gov Studies
Summary
This randomized, parallel, single-blind clinical trial (NCT07546318) registered by NIH on April 22, 2026, compares percutaneous electrical nerve stimulation (PENS) versus transcutaneous electrical nerve stimulation (TENS) for improving hand function in people with multiple sclerosis. Participants receive simultaneous stimulation of the median, radial, and ulnar nerves and are assessed at baseline, immediately after intervention, and 72 hours later. The study evaluates four outcomes: fine manual dexterity, gross manual dexterity, pinch strength, and tactile sensitivity.
“This randomized, parallel, single-blind clinical trial aims to compare the immediate and short-term effects of percutaneous electrical nerve stimulation (PENS) versus transcutaneous electrical nerve stimulation (TENS), applied simultaneously to the median, radial, and ulnar nerves, on hand function in people with multiple sclerosis.”
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What changed
This ClinicalTrials.gov entry registers a new randomized clinical trial (NCT07546318) comparing two electrical nerve stimulation approaches—percutaneous (PENS) and transcutaneous (TENS)—applied to the median, radial, and ulnar nerves of multiple sclerosis patients with hand function impairment. The study employs a parallel, single-blind design with three assessment time points. For affected parties, this trial represents an emerging research option for patients seeking non-pharmacological interventions for MS-related hand dysfunction, though it does not establish any compliance or regulatory obligations.
Archived snapshot
Apr 23, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
PENS vs TENS for Hand Function in Multiple Sclerosis
N/A NCT07546318 Kind: NA Apr 22, 2026
Abstract
This randomized, parallel, single-blind clinical trial aims to compare the immediate and short-term effects of percutaneous electrical nerve stimulation (PENS) versus transcutaneous electrical nerve stimulation (TENS), applied simultaneously to the median, radial, and ulnar nerves, on hand function in people with multiple sclerosis. Participants will be assessed at baseline, immediately after the intervention, and 72 hours later. Outcomes include fine manual dexterity, gross manual dexterity, pinch strength, and tactile sensitivity.
Conditions: Multiple Sclerosis
Interventions: Percutaneous Electrical Nerve Stimulation (PENS), Transcutaneous Electrical Nerve Stimulation (TENS)
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