EP4153578A1 - Chromen-4-one Derivatives (Flavones) as CK2 Inhibitors for Neuroinflammation - Salk Institute
Summary
The EPO published patent application EP4153578A1 on April 15, 2026, covering chromen-4-one derivatives such as flavones for use as casein kinase 2 (CK2) inhibitors in the treatment of neuroinflammation. The applicant is the Salk Institute for Biological Studies, with inventors Ioana I. Nitulescu, Fred H. Gage, and James K. Tucker. The application is classified under IPC subclasses C07D 311/22, C07D 311/28, and multiple other organic chemistry codes, with pharmaceutical composition claims under A61K 31/352 and A61K 31/443.
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GovPing monitors EPO Patent Bulletin - Organic Chemistry (C07D) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 63 changes logged to date.
What changed
The EPO published patent application EP4153578A1 on April 15, 2026, covering chromen-4-one derivatives (including flavones) for use as casein kinase 2 (CK2) inhibitors in treating neuroinflammation. The application names the Salk Institute for Biological Studies as applicant and Ioana I. Nitulescu, Fred H. Gage, and James K. Tucker as inventors. IPC classifications span C07D organic chemistry subclasses and A61K pharmaceutical composition subclasses. Designated states cover 29 European jurisdictions including all EU member states.\n\nPharmaceutical companies and researchers developing kinase-inhibitor therapies for neuroinflammatory conditions should review the scope of the claims to assess potential freedom-to-operate considerations. The patent's publication establishes a priority date and makes the technical disclosure publicly available, which may inform future R&D strategy in CK2-inhibition space.
Archived snapshot
Apr 26, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
CHROMEN-4-ONE DERIVATIVES, SUCH AS E.G. FLAVONES, FOR USE AS CK2 INHIBITORS FOR THE TREATMENT OF NEUROINFLAMMATION
Publication EP4153578A1 Kind: A1 Apr 15, 2026
Applicants
Salk Institute for Biological Studies
Inventors
NITULESCU, Ioana I., GAGE, Fred H., TUCKER, James K.
IPC Classifications
C07D 311/22 20060101AFI20211126BHEP C07D 311/28 20060101ALI20211126BHEP C07D 405/04 20060101ALI20211126BHEP C07D 413/04 20060101ALI20211126BHEP C07D 405/12 20060101ALI20211126BHEP C07D 413/12 20060101ALI20211126BHEP C07D 407/04 20060101ALI20211126BHEP C07D 471/04 20060101ALI20211126BHEP C07D 498/04 20060101ALI20211126BHEP C07D 407/06 20060101ALI20211126BHEP C07D 401/10 20060101ALI20211126BHEP C07D 417/14 20060101ALI20211126BHEP C07D 405/14 20060101ALI20211126BHEP A61K 31/352 20060101ALI20211126BHEP A61K 31/443 20060101ALI20211126BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
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