CGF Plug Study: Tooth Extraction Pain and Bone Density
ClinicalTrials.gov Studies
Summary
The National Institutes of Health has registered a new clinical trial (NCT07542795) on ClinicalTrials.gov evaluating Concentrated Growth Factor (CGF) plugs in patients undergoing simple, non-surgical tooth extraction. The study will monitor post-operative pain levels at 1, 3, and 7 days and measure alveolar bone density via CBCT imaging at baseline and 3 months. The goal is to determine whether CGF plugs reduce patient discomfort and preserve bone density for future dental implant procedures.
What changed
The National Institutes of Health published a clinical trial registration on ClinicalTrials.gov for NCT07542795, a single-site observational study. The study will enroll participants requiring a single, non-surgical tooth extraction and place a CGF plug (a third-generation healing material derived from the patient's own blood) into the extraction socket. Two primary endpoints are measured: patient-reported pain on a 0-10 scale at 1, 3, and 7 days post-procedure; and alveolar bone density via CBCT imaging at baseline and 3 months. Conditions under study include odontectomy (tooth extraction), socket preservation, and postoperative pain management.
For compliance and clinical operations teams: this is an informational registry entry with no immediate regulatory obligations. Sponsors or investigators conducting similar socket preservation or pain management research may wish to note the study's outcome measures and CBCT imaging protocol as a reference point for study design. No compliance deadlines, penalties, or mandatory actions are associated with this notice.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.
N/A NCT07542795 Kind: NA Apr 21, 2026
Abstract
This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions. CGF contains a dense matrix of growth factors and regenerative cells designed to enhance wound healing and tissue regeneration.
Participants requiring a single, non-surgical tooth extraction will have a CGF plug placed into the empty socket immediately following the procedure. The researchers will then monitor two main factors:
- Post-operative Pain: Patients will record their pain levels on a scale of 0 to 10 at 1, 3, and 7 days after the extraction.
- Bone Density: Using specialized imaging (CBCT), the researchers will measure how well the bone heals and fills the socket immediately after the procedure and again at 3 months.
The goal of this research is to determine if CGF plugs can effectively reduce patient discomfort and help preserve bone density, which is critical for future dental treatments like implants.
Conditions: Odontectomy (Tooth Extraction), Socket Preservation and Healing Following Simple, Non-surgical Extraction, Alveolar Bone Density and Postoperative Pain Management, Periapical Radiolucency
Interventions: Concentrated Growth Factor (CGF) Plug
Related changes
Get daily alerts for ClinicalTrials.gov Studies
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from NIH.
The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when ClinicalTrials.gov Studies publishes new changes.
Subscribed!
Optional. Filters your digest to exactly the updates that matter to you.