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Priority review Notice Added Final

Acting AG Reschedules Medical Marijuana to Schedule III Under CSA

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Summary

Acting Attorney General Todd Blanche issued the Medical Rescheduling Final Order on April 22, 2026, reclassifying FDA-approved marijuana products and state-licensed medical marijuana from Schedule I to Schedule III under the Controlled Substances Act, effective immediately. The order establishes an expedited DEA registration pathway allowing state medical marijuana licensees to apply using existing state credentials, with a 60-day window during which applicants may continue operating while review is pending. State-licensed entities gain immediate relief from Section 280E of the Internal Revenue Code, which previously disallowed ordinary business deductions for Schedule I and II controlled substance trafficking; retrospective relief for prior tax years remains subject to separate Treasury Department action.

Why this matters

State-licensed medical marijuana businesses have a 60-day window from April 22, 2026 to file expedited DEA registration applications and continue operating under their state licenses during review. Businesses with open tax years or pending IRS disputes should preserve all records and monitor Treasury guidance on retrospective Section 280E relief — this relief is not automatic and requires separate Treasury action.

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Published by Fox Rothschild on jdsupra.com . Detected, standardized, and enriched by GovPing. Review our methodology and editorial standards .

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JD Supra is the legal industry's open library where US law firms publish client alerts and regulatory analysis. The Healthcare section aggregates everything from partners covering CMS reimbursement, HIPAA enforcement, FDA compliance, healthcare M&A, fraud and abuse, payer-provider disputes, telehealth, and the fast-moving state regulation of healthcare AI. Around 250 alerts a month. Watch this if you run a hospital legal department, advise digital health startups, manage payer compliance, or track how state Medicaid agencies and HHS-OIG actually enforce the rules they publish. The signal-to-noise ratio is genuinely good because firms only publish when they have something concrete to say to their clients. GovPing pulls each alert with the firm name, author, and topic.

What changed

The Medical Rescheduling Final Order moves FDA-approved marijuana products and state-licensed medical marijuana from Schedule I to Schedule III under the Controlled Substances Act. Prior to this order, marijuana was classified as a Schedule I controlled substance with no accepted medical use and high abuse potential, restricting state-licensed medical marijuana businesses from accessing ordinary federal business deductions under Section 280E of the Internal Revenue Code. The order enables state-licensed manufacturers, distributors, and dispensaries to claim ordinary business deductions for federal tax purposes prospectively from April 22, 2026, and opens a pathway for retrospective relief from prior years subject to Treasury Department action.

Affected state-licensed medical marijuana businesses should take immediate action to apply for DEA registration within the 60-day expedited review window and update accounting practices to reflect newly available deductions. Entities with open tax years or pending IRS disputes should preserve records and monitor Treasury guidance on retrospective Section 280E relief. The order also modifies Single Convention import and export requirements, requiring DEA permits for rescheduled marijuana products. Participation requests for the June 29, 2026 DEA hearing must be filed by May 20, 2026 (paper) or May 24, 2026 (electronic).

What to do next

  1. State-licensed medical marijuana businesses should promptly apply for DEA registration by submitting proof of their state license along with applicable DEA forms
  2. Licensees should consult tax counsel regarding Section 280E relief and potential retrospective relief

Hearing

Date
2026-06-29
Location
700 Army Navy Drive, Arlington, Virginia 22202

CFR references

21 CFR 1312.30

Named provisions

Section 280E Medical Rescheduling Final Order Notice of Hearing on Proposed Rescheduling

Citations

21 U.S.C. § 811(d)(1) authority for expedited scheduling
21 CFR 1312.30 import/export permit requirements amended
21 U.S.C. § 825(c) statutory warning requirement referenced
Executive Order 14370 (December 18, 2025) directive for rescheduling rulemaking

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Last updated

Classification

Agency
Fox Rothschild
Published
April 24th, 2026
Comment period closes
May 24th, 2026 (30 days)
Instrument
Notice
Branch
Executive
Legal weight
Non-binding
Stage
Final
Change scope
Substantive
Docket
DEA-1362

Who this affects

Applies to
Medical marijuana businesses Drug manufacturers
Industry sector
4453 Cannabis
Activity scope
DEA registration Federal tax compliance Import/export permitting
Geographic scope
United States US

Taxonomy

Primary area
Cannabis
Operational domain
Regulatory Affairs
Topics
Taxation Pharmaceuticals

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