Neural Basis of the Effect of EMDR Therapy
ClinicalTrials.gov Studies
Summary
A clinical trial (NCT07550556) investigating the neurophysiological effects of Butterfly Tapping (BT), a self-administered form of alternating bilateral stimulation, enrolled 46 Post-Traumatic Stress Disorder patients randomly assigned to experimental or control groups. The experimental group received a 15-minute BT session while emotional reactivity was assessed via detection tasks during EEG recording, focusing on Late Positive Potential (LPP) amplitude changes. Results showed significant LPP reduction in the experimental group at T1 compared to T0, with no change in the control group, providing preliminary evidence that BT may reduce cortical reactivity to negative emotional stimuli.
“These findings provide preliminary neurophysiological evidence that BT may reduce cortical reactivity to negative emotional stimuli in young clinical populations, supporting its potential as a simple and accessible strategy capable of modulating affective responsiveness.”
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What changed
This ClinicalTrials.gov study entry documents research findings on Butterfly Tapping (BT), a self-administered bilateral stimulation technique, as a potential intervention for Post-Traumatic Stress Disorder. The study enrolled 46 PTSD patients who were randomly assigned to receive either a 15-minute BT session or no intervention, with emotional reactivity measured through event-related potentials (specifically Late Positive Potential amplitude) during EEG recording.
For healthcare providers and clinical researchers, these preliminary findings suggest BT may offer a simple, accessible strategy for modulating affective responsiveness in young clinical populations. The topographically central distribution of LPP modulation is consistent with higher-order integrative and evaluative neural processes, though further research would be needed to establish clinical efficacy beyond these neurophysiological indicators.
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Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Neural Basis of the Effect of EMDR Therapy
N/A NCT07550556 Kind: NA Apr 24, 2026
Abstract
This study aimed to investigate the effects of a single session of Butterfly Tapping (BT), a self-administered form of alternating bilateral stimulation, on emotional reactivity and its neurophysiological correlates. 46 Post-Traumatic Stress Disorder patients will be randomly assigned to an experimental (Exp) or control (Con) group. The Exp group performed a 15-minute session of BT. Emotional reactivity was assessed before and after the stimulation using a detection task with emotional visual stimuli, presented during electroencephalographic (EEG) recording. EEG analyses were conducted using the event-related potential (ERP) method, specifically focusing on the differential amplitude (negative minus neutral) of the Late Positive Potential (LPP), a centro-parietal component associated with sustained processing of emotionally salient stimuli. Results revealed a significant LPP reduction in the Exp group at T1 compared to T0, whereas no change emerged in the Con group. The topographical distribution of the modulation was predominantly central, consistent with models implicating the LPP in higher-order integrative and evaluative processes. These findings provide preliminary neurophysiological evidence that BT may reduce cortical reactivity to negative emotional stimuli in young clinical populations, supporting its potential as a simple and accessible strategy capable of modulating affective responsiveness.
Conditions: PTSD - Post Traumatic Stress Disorder
Interventions: Butterfly Tapping (BT), No intervention control
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