Changeflow GovPing Environment Draft Human Health Hazard Evaluation for HHCB C...
Priority review Consultation Added Draft

Draft Human Health Hazard Evaluation for HHCB Chemical

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Summary

EPA has released a draft human health hazard evaluation for HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran), a synthetic polycyclic musk used as a fragrance ingredient in consumer products. The draft evaluation assesses potential health risks from exposure to HHCB through various routes including dermal, inhalation, and oral pathways. EPA is seeking public comment on the scientific methodology and conclusions of this hazard evaluation before finalizing its assessment.

What changed

EPA has issued a draft human health hazard evaluation for HHCB (Galaxolide), a synthetic musk fragrance ingredient. The document evaluates potential health hazards from exposure to this chemical, which is used in perfumes, cosmetics, soaps, and other consumer products. The evaluation assesses endpoints including dermal sensitization, developmental toxicity, and other health effects.

Manufacturers and importers of products containing HHCB should review the draft evaluation and prepare to submit comments on the scientific methodology and risk conclusions. While this draft does not impose binding obligations, it signals EPA's continued attention to fragrance ingredients and could inform future regulatory actions under TSCA if health concerns are substantiated.

What to do next

  1. Submit public comments on the draft hazard evaluation
  2. Review the scientific methodology and findings
  3. Monitor for the comment close date announcement

Archived snapshot

Apr 14, 2026

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Last updated

Classification

Agency
EPA
Instrument
Consultation
Legal weight
Non-binding
Stage
Draft
Change scope
Minor
Document ID
EPA-HQ-OPPT-2026-1189-0009
Docket
EPA-HQ-OPPT-2026-1189

Who this affects

Applies to
Chemical manufacturers Manufacturers Importers and exporters
Industry sector
3254 Chemical Manufacturing
Activity scope
Chemical hazard evaluation Fragrance ingredient assessment Risk assessment
Geographic scope
United States US

Taxonomy

Primary area
Environmental Protection
Operational domain
Compliance
Topics
Public Health Chemical Manufacturing Consumer Protection

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