Autosomal DNA Relationship Testing Guidance for Practitioners (FSR-GUI-0014)
Summary
The Forensic Science Regulator has published updated guidance (FSR-GUI-0014) on autosomal DNA short tandem repeat (STR) relationship testing, replacing the earlier FSR-G-228 document. The guidance provides practitioners with recommended principles for conducting relationship testing using autosomal DNA markers, including STRs, In/Dels, and SNPs. While the document applies specifically to STR markers, the underlying principles may be extended to other autosomal marker classes.
“This document provides guidance and recommendations to practitioners providing relationship testing services using autosomal DNA short tandem repeat profiling.”
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What changed
The Forensic Science Regulator has issued FSR-GUI-0014, a comprehensive guidance document on autosomal DNA relationship testing that supersedes the previous FSR-G-228 standard. The guidance covers autosomal STR profiling methodology and extends its principles to other autosomal marker types including In/Dels and SNPs. Practitioners providing relationship testing services should review the updated guidance to ensure their procedures align with current regulatory expectations.
Forensic laboratories and practitioners conducting DNA relationship testing for legal proceedings should update their standard operating procedures to reflect the principles outlined in FSR-GUI-0014. While the document maintains the same ethos as its predecessor, specific updates may affect laboratory accreditation and quality assurance requirements for forensic DNA analysis.
Archived snapshot
Apr 15, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Guidance
Autosomal DNA relationship testing (FSR-GUI-0014)
Guidance for practitioners on autosomal STR relationship testing, replacing FSR‑G‑228. Principles also apply to other autosomal markers like In/Dels and SNPs.
From: Forensic Science Regulator Published 24 February 2026 Get emails about this page
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Autosomal DNA relationship testing (accessible)
Ref: FSR-GUI-0014
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Autosomal DNA relationship testing
Ref: FSR-GUI-0014
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Details
This document provides guidance and recommendations to practitioners providing relationship testing services using autosomal DNA short tandem repeat profiling. This document applies only to short tandem repeat (STR) markers, although the ethos of the guidelines can be applied to other classes of autosomal markers such as In/Dels and single nucleotide polymorphisms (SNPs).
This document replaces the previously published FSR-G-228: DNA relationship testing using autosomal short tandem repeats, which you can access at the National Archives.
Updates to this page
Published 24 February 2026
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