Healthcare & Life Sciences — April 14, 2026

US12599362B2 - TERUMO - 3D Medical Image Processing Device

USPTO granted patent US12599362B2 to TERUMO KABUSHIKI KAISHA for an image processing device that displays three-dimensional biological tissue data as a 3D image with 2D cross-sectional views. The patent covers technology for forming cutting regions in 3D medical imaging data to expose lumens and display corresponding cross-sections.

Wearable Device for Hands-Free Operation of an Ultrasound Probe

The USPTO granted patent US12599363B2 to GE Precision Healthcare LLC on April 14, 2026, for a wearable device enabling hands-free operation of an ultrasound probe. The invention comprises a mount with a spherical outer surface and opening to receive a probe, a base with an inner circumferential surface for selective rotation about at least one axis, and a lock to secure the probe position and orientation. The patent contains 20 claims.

Boston Scientific Scimed - Ultrasonic Imaging ICE Catheter System Patent

USPTO granted Patent US12599361B2 to Boston Scientific Scimed, Inc. for an ICE imaging system featuring an intracardiac echocardiography catheter with a micro-electromechanical phased array ultrasound transducer. The patent covers a catheter with 6 French or smaller outer diameter designed for delivery through venous systems into heart chambers for pacemaker and ICD lead placement imaging. The patent protects the electronic flex cable architecture and signal processing methods for constructing heart images from ultrasound beam transmissions.

Ultrasound Simulation System Patent, Simhawk Ltd

USPTO granted patent US12599364B2 to Simhawk Ltd on April 14, 2026, for an ultrasound simulation system. The invention comprises a camera, physical tridimensional reference element attached to an ultrasound transducer, and processing module that digitally images the reference element, determines spatial data relative to a virtual location-identifying orientation, and displays ultrasound data when spatial data matches. The patent contains 24 claims under CPC classification A61B 8/4245.

Stabilizing Transnasal Balloon Sheath Patent US12599365B2

USPTO granted patent US12599365B2 to Medtronic, Inc. for a transnasal transesophageal balloon catheter with compliant balloons, fluid channels, and a probe guide lumen of less than 15 French. The patent covers technology for slidably and rotatably receiving an ultrasound probe during transnasal procedures.

Stethoscope Kit

USPTO granted patent US12599355B2 to BINJIANG INSTITUTE OF ZHEJIANG UNIVERSITY on April 14, 2026. The patent covers a stethoscope kit including a storage cylinder, protective shell, and electronic stethoscope with integrated charging capability. Inventors are Weize Xu and Qiang Shu, with 6 claims allowed under CPC classifications A61B 7/04 and A61B 2562/0204.

US Patent B2, Fetal Heart Rate Monitoring System, Philips

The USPTO granted Patent US12599356B2 to Koninklijke Philips N.V. for an AI-assisted ultrasound fetal heart rate monitoring system. The system uses a trained object detection model to automatically locate a fetal heart in ultrasound images and switches the probe to Doppler mode for heart rate computation. This patent provides Philips with enforceable property rights for the disclosed technology.

Ultrasound Diagnostic Apparatus and Method - US12599359B2

USPTO granted Fujifilm Corporation Patent US12599359B2 for an ultrasound diagnostic apparatus and control method capable of displaying blood vessel measurements within an ultrasound image display range. The apparatus includes features for detecting regions of interest and positioning blood vessel information display accordingly. The patent includes 20 claims and was filed on January 31, 2022.

Boston Scientific Scimed Ultrasonic Imaging Ablation Catheter Patent

The USPTO granted Patent US12599360B2 to Boston Scientific Scimed, Inc. covering an integrated ultrasonic imaging and ablation catheter system. The invention utilizes MEMS-based Piezoelectric Micromachined Ultrasonic Transducer (pMUT) technology and dual electrode carrier assemblies for cardiac ablation procedures. The patent contains 15 claims and was filed on October 24, 2022.

Methods and Systems for Ultrasound Imaging of a Body in Motion

The USPTO granted Patent US12599358B2 to inventors Philippe Cormier, Jonathan Poree, and Jean Provost for methods and systems enabling ultrasound imaging of a body in motion. The patent covers computing Lagrangian coordinates from Eulerian-based ultrasound images and forming Lagrangian-based ultrasound images using those coordinates. The patent contains 20 claims and was filed on August 5, 2021.

Complaint Filed by Center for Tobacco Products

The FDA Center for Tobacco Products (CTP) filed a complaint with tracking number FDA-2026-H-3841. The complaint was submitted on April 14 and is now accessible via regulations.gov. Only a PDF attachment of the complaint is available for download; no summary documents are viewable on the regulatory portal.

B.E. Meyers & Co. Variance Application - CDRH

B.E. Meyers & Co., Inc. has submitted a variance application to the FDA Center for Devices and Radiological Health (CDRH). The application requests permission to deviate from specific regulatory requirements applicable to the company's medical device operations. FDA has received and posted the application for public access via Regulations.gov under docket FDA-2025-V-4733-0001.

FDA Center for Tobacco Products Complaint Regarding Retailer Violation

The FDA Center for Tobacco Products (CTP) filed a complaint (FDA-2026-H-3866-0001) on April 14. The complaint relates to potential violations of federal tobacco product regulations, specifically concerning retailer compliance with sales and marketing requirements. The document represents a formal complaint filing within the FDA's regulatory enforcement process.

Variance Amendment - SRS Visual, CDRH

FDA's Center for Devices and Radiological Health (CDRH) issued a variance amendment related to SRS Visual. The variance was filed under docket FDA-2026-V-2145. The specific regulatory requirements being modified and the scope of the variance cannot be determined from available metadata as the full document content is not accessible.

Background Material for Docket FDA-2026-P-4022

FDA published background material under docket FDA-2026-P-4022 on April 14. The document contains supporting information related to a regulatory matter before the agency. No specific regulatory requirements, compliance deadlines, or penalties are stated in the available filing.

Variance Application, Christ The King Lutheran Church, FDA, North Carolina

Christ The King Lutheran Church in North Carolina submitted a variance application to the FDA Center for Devices and Radiological Health (CDRH) under docket FDA-2026-V-3505. The specific regulatory requirements or medical device standards at issue are not disclosed in the available metadata. No documents are currently available for public review on Regulations.gov.

FDA CDRH Approves Variance for Church

FDA CDRH Approves Variance for Church

ECG Electrode Positioning Method and Device (US12599354B2)

USPTO granted patent US12599354B2 to Analog Devices International Unlimited Company on April 14, 2026. The patent covers methods for positioning six ECG chest electrodes based on body height to ensure reproducible placement in serial measurements, and a device implementing the method. The invention addresses placement accuracy issues, particularly in obese subjects, by eliminating reliance on subjective anatomic landmarks.

Speed Variable TDS Operation in X-Ray Imaging Systems

The USPTO granted patent US12599348B2 to GE Precision Healthcare LLC covering TDS (Time-Delayed Summation) acquisition systems in x-ray imaging with variable scan speed capability. The patent (19 claims, filed September 7, 2023) enables constant sampling distance between strobes regardless of scan velocity, producing undistorted images. Inventors include Adam Manders, Michael R. Buchholz, and James Wear.

Pet Health Radar Monitoring Patent - Franklin Technology

The USPTO granted Patent US12599343B2 to Franklin Technology Inc. on April 14, 2026, covering a radar-based apparatus and method for monitoring pet health status. The invention measures heart rate and breathing rate of pets using radar sensors, detects health abnormalities, and transmits notification messages to pet owners' electronic terminals. The patent includes 7 claims and covers A61B classifications related to physiological measurement.

Support Apparatus System and Method for Positioning a Patient

USPTO granted patent US12599345B2 to Qfix Systems LLC covering a knee and foot support apparatus system for positioning patients during radiotherapy and imaging procedures. The patent claims adjustability features for superior-inferior axis positioning in gross and fine increments. The patent contains 15 claims and was filed on September 14 2020.

CT Imaging Method for Vasa Vasorum Density Measurement in Vascular Wall

USPTO granted Patent US12599350B2 to inventor Morteza Naghavi on April 14, 2026. The patent covers a computed tomography method for imaging vasa vasorum density in blood vessels including coronary and carotid arteries and the aorta. The method involves administering a contrast agent, performing contrast-enhanced CT scans, measuring Hounsfield distribution, and analyzing data to determine vasa vasorum density metrics for assessing cardiovascular risk and recommending diagnostic or therapeutic next steps.

Visualization of Touch Panel to Object Distance in X-ray Imaging

USPTO granted patent US12599353B2 to Siemens Shanghai Medical Equipment Ltd. on April 14, 2026. The patent covers methods and apparatus for visualizing touch panel to object distance in X-ray imaging, including generating three-dimensional images of detected subjects and creating identifiers to represent distances. The patent contains 18 claims.

FY 2027 HHS Budget Proposes Cuts, Restructuring

Holland & Knight LLP summarizes the Trump Administration's FY 2027 HHS Budget released April 3, 2026. The budget proposes targeted funding reductions across federal health programs, structural changes aligned with the Make America Healthy Again (MAHA) agenda, and increased oversight. Major entitlement reforms are notably absent, with the administration potentially pursuing Medicare and Medicaid changes through regulatory or congressional engagement rather than the budget process.

FinCEN Health Care Fraud Advisory and Proposed Whistleblower Rule

FinCEN issued a health care fraud advisory on March 30, 2026, urging financial institutions to identify and report suspicious activity tied to Medicare, Medicaid, and other federal and state health care benefit program fraud, in coordination with the FBI and HHS Office of Inspector General. One day later, FinCEN published a proposed rulemaking to implement its whistleblower incentives and protections program under the Anti-Money Laundering Act of 2020 and AML Whistleblower Improvement Act of 2022.

Healthcare Sector Targeted in 12% of 2025 Activist Campaigns

Healthcare Sector Targeted in 12% of 2025 Activist Campaigns

National AI Legislative Framework: Healthcare Entity Implications

The White House issued a National Policy Framework for AI on March 20, 2026, calling on Congress to establish a federal policy that preempts state AI laws imposing 'undue burdens.' The Framework has six objectives including protecting children and encouraging AI innovation. No legislation has been passed; current state AI laws (Utah AI Act, Colorado AI Act, California AI amendments) remain in effect. The Framework does not create a new federal rulemaking body—existing agencies like CMS, DOJ, and FDA will continue governing healthcare AI.

DOJ Indicts Osteopathic Physician for Receiving, Selling Misbranded Peptide Drugs

The DOJ indicted a licensed osteopathic physician in Utah for allegedly receiving and selling misbranded drugs from China, marking an escalation in federal peptide enforcement. A Massachusetts medspa owner also pleaded guilty to importing merchandise contrary to law and selling counterfeit drugs and devices. This enforcement wave aligns with the FDA's first warning letter to a clinic regarding unapproved drug sources for aesthetic treatments.

EU Pharma Faces New Environmental Risk Assessment Requirements Under Revised Pharmaceutical Legislation

A&O Shearman analyzes EU environmental and sustainability legislation affecting pharmaceutical manufacturers, including provisional agreements on the Corporate Sustainability Due Diligence Directive and Corporate Sustainability Reporting Directive. The analysis focuses on new environmental risk assessment requirements under revised pharmaceutical legislation that will be integrated into marketing authorization applications, with provisions allowing authorities to refuse, suspend, or revoke marketing authorizations for insufficient ERAs or unaddressed environmental risks.

Two Years On: How UPC Has Impacted European Patent Litigation in Life Sciences

A&O Shearman examines two years of Unified Patent Court (UPC) operations since its June 2023 launch. Over 480 patents have been litigated in the court, with actions steadily increasing. Initially reluctant pharmaceutical players have begun utilizing UPC proceedings, attracted by efficient case management and patentee-friendly decisions. The Court of Appeal has issued harmonizing guidance on key patent validity issues including claim interpretation, inventive step, added matter, sufficiency, and plausibility.

Taking The Pulse Episode 273: Navigating FDA Regulation for Life Sciences Companies

Maynard Nexsen published Episode 273 of its 'Taking The Pulse' healthcare and life sciences video podcast discussing FDA regulatory developments for life sciences companies. The episode features attorney Christin Carey covering tariffs affecting pharma and biotech, evolving FDA guidance for digital health and clinical decision support tools, and the agency's approach to AI, cybersecurity, and emerging technologies.

Q&A: Why Data Provenance Is Critical to AI-Powered Drug Discovery

A&O Shearman published a Q&A article examining data provenance considerations for AI-powered drug discovery. The article addresses transaction risks, IP ownership, data usage rights, and regulatory compliance in AI-biotech partnerships. It discusses challenges around patient consent for secondary use of clinical trial data in machine learning training and the importance of understanding where data comes from and under what terms it can be used.

CMS Finalizes Contract Year 2027 Medicare Advantage and Part D Final Rule and Rate Announcement

CMS issued the CY 2027 Medicare Advantage and Part D Final Rule on April 2, 2026, along with the CY 2027 Rate Announcement on April 6, 2026. The Rate Announcement projects a net average increase in MA payments of 2.48%, representing over $13 billion in additional payments to plans. The Final Rule makes significant changes to the Star Ratings system, codifies IRA provisions, refines supplemental benefits regulations, and implements deregulatory measures under Executive Order 14192.

FDA Proposes 20+ Changes Streamlining Biosimilar, Generic Development

The FDA's FY 2027 budget justification includes more than 20 legislative proposals spanning drug and biologic approval pathways, supply chain oversight, and advertising standards. Key provisions include amending Section 351 of the Public Health Service Act to remove the separate statutory standard for biosimilar interchangeability, creating an abbreviated licensure pathway for biological products analogous to the 505(b)(2) pathway, and strengthening supply chain transparency requirements. The FDA has approved 83 biosimilars to date, with 37 approved between January 2024 and January 2026 alone.

FDA Reversal on Injectable Peptides Creates Investor Risk

Guidepost Solutions analyzes FDA's reversal of its 2023 ban on 14 injectable peptides, including BPC-157, ipamorelin, and Thymosin Alpha-1. The regulatory shift, driven by HHS Secretary Kennedy's advocacy, allows these compounds to return to Category 1 where licensed compounding pharmacies can prepare them under physician prescription. However, FDA's scientific leadership reportedly retains safety concerns including immunogenicity, organ toxicity, and product impurity that drove the original restrictions.

EU Commission Proposes MDR and IVDR Revision to Simplify Medical Device Rules

The EU Commission published a 170-page proposal on December 16, 2025, revising the Medical Device Regulation (EU) 2017/745 and In Vitro Diagnostic Regulation (EU) 2017/746. The proposal aims to streamline requirements and reduce administrative burden for manufacturers and notified bodies while maintaining public health protection. Key changes include unlimited certificate validity, revised classification rules for surgical instruments and software, relaxed PRRC requirements for small enterprises, and reduced post-market surveillance reporting frequency.

Nucleic Acid Complexes with Cationic/Anionic Polymers and RNA Molecules

The USPTO published patent application US20260096998A1 for nucleic acid complexes comprising cationic polymers, anionic polymers, and monomeric RNA molecules. The disclosed complexes feature a core structure where the cationic polymer and RNA molecule are encapsulated by the anionic polymer. The application covers linear and non-linear configurations of these complexes for therapeutic uses.

Method and System for Confirmation of Microneedle-Based Analyte-Selective Sensor Insertion via Electrical Interrogation

USPTO granted patent US12599337B1 to Biolinq Incorporated on April 14, 2026, covering a system and method for confirming microneedle sensor insertion into viable tissue using electrical interrogation. The invention applies electrical stimulus between electrodes within an analyte-selective sensor array (200-2000 μm vertical extent) to measure a response and compare it against a reference value to determine insertion success. If insertion fails, the user is instructed to apply additional force or re-apply the sensor.

US12599336B2 - Earring-Based Continuous Physiological Monitoring Wearable Device

USPTO granted patent US12599336B2 to inventors Zhang, Liu, Ji, and Fu for a wearable earring device with integrated sensors for continuous physiological monitoring. The apparatus comprises an earring body with a sensor module positioned to collect biological signals at the auricle, including tonoarteriogram (TAG) signals. The patent application was filed November 29, 2022, and the grant issued April 14, 2026, with 9 claims.

Non-invasive Assessment of Glymphatic Flow and Neurodegeneration from Wearable Device

USPTO granted patent US12599332B2 to Applied Cognition, Inc. for a computer-implemented method and system that processes neurophysiological and neurovascular data recorded during sleep from wearable devices to assess glymphatic flow and predict neurodegeneration markers. The patent covers function mapping from the recorded data to target markers including glymphatic flow markers, molecular analysis markers, and neuroimaging markers of neurodegeneration. The patent contains 30 claims.

Hyperspectral Image-Guided Ocular Imager for Alzheimer's Disease Pathologies

USPTO granted patent US12599331B2 to RETISPEC INC. on April 14, 2026, for a non-invasive hyperspectral eye imaging device designed to detect Alzheimer's Disease-associated Tauopathy biomarkers. The device uses spectral reflectance imaging with a fundus camera to identify pathology indicators in retinal tissue.

Wearable Medical Device Zoneless Arrhythmia Detection Patent

USPTO granted patent US12599330B2 to West Affum Holdings DAC on April 14, 2026. The patent covers wearable medical devices with zoneless arrhythmia detection using a sudden rate change onset algorithm. The invention includes physiological sensors and arrhythmia detection algorithms for patient monitoring.

Deflectable Elongated Guidewire Assembly

USPTO granted patent US12599338B2 to Boston Scientific Medical Device Limited on April 14, 2026 for a deflectable elongated guidewire assembly used in medical procedures. The patent covers a guidewire with a distal segment configured to be selectively maneuvered along an introducer assembly and to transmit tenting force to biological walls. The patent application was filed May 25, 2021 and contains 11 claims.

Implantable Micro-Biosensor and Method for Operating the Same

USPTO granted patent US12599318B2 to Bionime Corporation on April 14, 2026, for an implantable micro-biosensor device. The invention includes a substrate with multiple working electrodes and a counter electrode configured to measure physiological signals and consume interfering substances. The patent contains 11 claims covering the biosensor architecture and operating method.

Micro Analyte Sensor Continuous Monitoring Device

USPTO granted patent US12599320B2 to Medtrum Technologies Inc. on April 14, 2026, covering a micro analyte sensor and continuous analyte monitoring device. The patent includes dual electrode groups operating at different frequencies for analyte detection with redundancy. The patent contains 9 claims.

Velano Vascular Phlebotomy Through Peripheral IV Catheter Patent

USPTO granted Velano Vascular patent US12599324B2 for systems and methods for phlebotomy through a peripheral IV catheter. The patent covers apparatus including a catheter, introducer with first and second members, locking mechanism, and actuator configured to move the catheter from within the introducer to extending past the peripheral IV line end. The patent has 7 claims and was assigned to Velano Vascular, Inc.

Device for Measuring a Pressure Differential

The USPTO granted patent US12599311B2 to Clinical Technology Limited for a device measuring pressure differentials. The device comprises a tube with a closed insertion portion for body insertion, at least one pressure sensor located in or on the insertion portion, and a processor configured to provide stimulus to the pressure sensor and correlate the response with pressure differential. The pressure sensor may comprise piezoelectric or electrocapacitive materials and may have different resonant frequencies.

Moisture-resistant Electrocardiography Monitor for Wearable Cardiac Diagnostics

USPTO granted patent US12599326B2 to Bardy Diagnostics, Inc. on April 14, 2026. The patent covers a moisture-resistant wearable ECG monitor featuring a flexible extended wear electrode patch and a reusable monitor recorder that snaps into a receptacle on the patch. The monitor is positioned along the sternal midline and is designed to capture P-wave and QRS interval signals for improved cardiac diagnostics.

Withings ECG Measurement Station Cardiac Monitoring Patent

USPTO granted Withings Patent US12599327B2 for an ECG measurement station incorporating control electrodes and a feedback loop circuit for cardiac monitoring. The patent contains 22 claims and lists inventors Jean-Louis Wang and Antoine Merlot. This represents routine patent issuance creating exclusive rights for the assignee with no immediate compliance obligations for other parties.

Devices and Methods for Assessing Pulmonary Status Using Optical Oxygenation Sensing

USPTO granted patent US12599321B2 to Cardiac Pacemakers, Inc. covering devices and methods for assessing pulmonary status using optical oxygenation sensing. The patent claims an oxygenation monitoring device with an optical emitter configured to emit light at wavelengths from 100 nm to 2000 nm and a detector to measure incident light propagating through lung tissue to determine oxygenation status. The patent application (No. 17864907) was filed on July 14, 2022, and contains 17 claims.

Health Trackers for Autonomous Targeting of Tissue Sampling Sites

The USPTO granted patent US12599313B2 to inventor Gil Travish on April 14, 2026. The patent covers health tracker devices configured to autonomously target tissue sampling sites using magnetic resonance spectral data. The scanner includes a magnet for field gradients, RF transmitting antenna, and RF sensing antenna to obtain spectral data from predetermined locations within a volume of interest. The patent contains 14 claims and was filed on June 23, 2022.

Measles Exposure Location Confirmed at Centennial Middle School Southeast Portland

Oregon Health Authority and Multnomah County public health officials confirmed a measles exposure location at Centennial Middle School in southeast Portland. Individuals present at the school between April 1-10, 2026 during school hours may have been exposed. Officials are urging potentially exposed individuals to contact their healthcare providers to determine measles immunity based on vaccination record, age, or laboratory evidence.

System and Methods for Connective Tissue Repair Using Scaffolds

The USPTO issued Patent US12599700B2 to The Children's Medical Center Corporation covering methods and devices for repair of torn or ruptured ligaments using scaffold devices. The patent includes 40 claims spanning methods of placement and fixation, notchplasty techniques, and delayed rehabilitation protocols. The invention is classified under CPC codes A61F 2/08 and relates to connective tissue scaffold technology.

Oral Appliance for Use with CPAP Headgear

The USPTO granted patent US12599740B2 to R.I.P., LLC on April 14, 2026, covering an oral appliance designed for use with nasal CPAP masks. Invented by Rob Veis, the patent contains 14 claims and includes an occlusal opening, interproximal protrusions for tooth retention, and a buccal wall to create an intraoral seal. The application was filed on March 8, 2021 (Application No. 17909722).

DPHHS Partners with Imagination Library to Promote Early Literacy for Montana Children

The Montana Department of Public Health and Human Services (DPHHS) announced a partnership with the Imagination Library of Montana to promote early literacy. The Early Childhood and Family Support Division will integrate Imagination Library promotion into existing programs including home visiting, early intervention, maternal health, child care, and WIC. The program currently serves over 29,000 Montana children under age five, approximately half of the eligible population.

Microbial Compositions and Methods for Fermented Foods

USPTO published patent application US20260096563A1 for microbial compositions comprising purified populations of microorganisms used in producing dough or baked food products. The compositions are designed to enhance fermentation by improving rheological properties, nutritional quality, and shelf-life of dough and baked food products. The application was filed on December 9, 2025, with inventors Cameron Martino and James Gaffney.

Thraustochytrids, Fatty Acid Compositions, and Methods - DSM Assets

USPTO published patent application US20260096578A1 by DSM IP Assets B.V. covering isolated thraustochytrid microorganisms, microbial oils, biomasses, compositions, and associated production and use methods. The application, filed August 13, 2025, lists six inventors and covers CPC classifications spanning food, cosmetic, and pharmaceutical applications.

Balloon-type Retinal Stimulation Device and Manufacturing Method - Patent Grant US12599769B2

The USPTO granted Patent US12599769B2 to Daegu Gyeongbuk Institute of Science and Technology for a balloon-type retinal stimulation device. The invention includes a substrate unit with an expandable insertion portion and a stimulation unit that contacts the retina. The device uses fluid injection to expand and conform to the retina's shape for optimal stimulation. The patent contains 10 claims and was filed on September 13, 2023.

Amazon Technologies - mmWave Radar Oxygen and Vital Signs Monitoring Patent

The USPTO granted Amazon Technologies Patent US12599307B1 for a method of concurrent monitoring of indoor oxygen concentration levels and human vital signs using mmWave radar sensors. The technology employs triangular and ramp-type chirp signals to detect vital signs such as heart rate and respiratory rate, while RSSI measurements at approximately 60 GHz determine oxygen concentration in the ambient environment. The patent includes 20 claims.

Pupil Dynamics Assessment System for Situational Awareness Competency Estimation

USPTO granted patent US12599306B2 to Rockwell Collins, Inc. covering a computer-implemented system and method for assessing operator performance by analyzing eye tracking data correlated with physiological data including heart rate. The system evaluates whether operators exhibit anticipatory responses, differentiates cognitively-initiated behaviors from environmentally-triggered behaviors, and assesses situational awareness competency. The patent contains 16 claims.

Configurable Hardware Platform for Physiological Monitoring

USPTO granted patent US12599304B2 to Bardy Diagnostics, Inc. for an implantable medical device featuring a configurable hardware platform for physiological monitoring. The device includes electrodes on a hollow housing, a microcontroller with non-volatile memory, an analog front end for ECG signal sensing, wireless transceiver for external data communication, and a receiving coil with charging circuit. The patent contains 19 claims.

Laryngoscope with Physiological Parameter Indicator

USPTO granted patent US12599300B2 to Covidien AG for a laryngoscope system featuring physiological parameter monitoring. The system includes a paired laryngoscope with camera and display that receives physiological data from a monitor, generating visual indicators for healthcare providers during procedures.

Sony Patent for ML-Based Eyesight Test System Using Eye Image Analysis

The USPTO granted Patent US12599303B2 to Sony Group Corporation on April 14, 2026, covering a machine learning-based eyesight test system. The system uses a processor and ML algorithm to estimate eyesight characteristics including myopia, hyperopia, and astigmatism from eye images. The patent application was filed February 28, 2023 and contains 17 claims defining the scope of the invention.

Sensor Device, System, and Method for Performing an Absolute Blood Pressure Measurement

USPTO granted patent US12599308B2 to AIT Austrian Institute of Technology GmbH on April 14, 2026. The patent covers a sensor device or system for performing absolute blood pressure measurements using a finger abutment surface, dual sensors measuring blood volume pulses and force/pressure, and processing circuitry to determine absolute blood pressure. The patent contains 17 claims.

System for Conducting Eye Examinations for Visual Acuity

USPTO granted patent US12599301B2 to Verily Life Sciences LLC on April 14, 2026, covering systems and methods for conducting eye examinations to assess visual acuity. The patent describes an optical subsystem positioned in front of one or both eyes of a user, which may be a handheld or head-worn device, capable of determining distance based on comparing a fixed visual indicator size to its detected size in a camera image. The system outputs eye examination images based on valid distance ranges and accepts user input for visual stimulus selection. The patent contains 22 claims.

Cat Diaper Patent - US12599509B2

USPTO granted patent US12599509B2 to Unicharm Corporation on April 14, 2026 for a cat diaper design. The invention includes a body portion with absorbent core, fastening tape, and a constricted portion that tapers toward the inner side. The patent names Daisuke Komatsubara and Yumi Matsumoto as inventors and contains 9 claims.

Kimberly-Clark Absorbent Article with Leak-Proof Containment Flaps

The USPTO granted Patent US12599510B2 to Kimberly-Clark Worldwide, Inc. on April 14, 2026. The patent covers an absorbent article with leak-proof containment flaps bonded using transverse ultrasonic point patterns. The invention restricts fluid leaks between bond lines while maintaining aesthetic appeal. The patent includes 20 claims and names Matthew X Majestic, Lynn Lynch, Janet E. Collins, Austin N. Pickett, Amanda L. Plump, Joseph J. Sina, and Lori A. Roocks as inventors.

LG Chem Absorbent Article Patent US12599511B2 Granted

The USPTO granted Patent US12599511B2 to LG Chem, Ltd. on April 14, 2026, covering an absorbent article with a superabsorbent polymer film designed to improve leak prevention in three-dimensional gathers. The patent application (18266063) was filed on May 11, 2022, and includes 6 claims.

US12599508B2 - Absorbent Articles with Frangible Pathways - Procter & Gamble

USPTO granted Patent US12599508B2 to The Procter & Gamble Company covering absorbent articles with elastic laminates and frangible pathways in front and/or back waist regions, along with methods and apparatuses for manufacturing such articles. The patent names eight inventors including Jeffry Rosiak, Michael Devin Long, Jason Edward Naylor, Michael Brian Quade, Matthew Alexander Gittings, Uwe Schneider, Jeromy Thomas Raycheck, and Keith Richard Willhaus. The patent contains 17 claims and was filed on June 27, 2023, under Application No. 18214750.

Stretch Layered Sheet, Disposable Wearing Article, and Manufacturing Method and Device

USPTO granted Patent US12599513B2 to ZUIKO CORPORATION on April 14, 2026. The patent covers a stretch layered sheet with thermal bonding between non-woven fabrics and film, featuring vents that provide air permeability in both stretched and non-stretched states. The invention also includes methods and devices for manufacturing the stretch layered sheet.

Daio Paper Disposable Diaper Patent US12599514B2

USPTO granted Patent US12599514B2 to Daio Paper Corporation on April 14, 2026, covering a disposable diaper design featuring absorber body compression areas for enhanced fit and wearer comfort. The patent includes 7 claims specifying round and oval compressed areas arranged at intervals in the width and front-back directions. This grant gives the assignee exclusive rights to the patented technology.

Feminine Napkin Assembly with Fluid Guide

USPTO granted Patent US12599512B2 to inventor Charity Collins for a feminine napkin assembly featuring a fluid guide that directs menstrual fluid to a desired location on the pad. The fluid guide includes an elongate member with a proximal end coupled to the upper surface of the menstrual pad and a distal end extending toward the front of the pad, which may be placed against or inside the user's vagina to minimize side, rear, or front leakage. The patent application (No. 17591936) was filed on February 3, 2022, and the granted patent contains 11 claims.

Surgical Robotic System with Integrated Navigation

USPTO granted patent US12599447B2 to Globus Medical, Inc. for a surgical robotic system with integrated navigation and multiple surgical arms. The patent covers devices and methods for robot-assisted surgery to assist with procedures including pedicle screws and interbody implants. The patent contains 19 claims with inventors Norbert Johnson and David C. Paul.

Robotic Surgical System with Removable Portion and Method of Disassembling Same (US12599446B2)

The USPTO granted Patent US12599446B2 to Cilag GmbH International for a robotic surgical system with a removable tool portion. The system includes a controller, surgical instrument, and tool with a disassembly feature that disconnects a portion of the instrument in response to controller instructions. The patent contains 20 claims and covers technology in CPC classifications A61B 34/32, A61B 50/30, and related surgical robotics categories.

Surgical Robotic Automation with Tracking Markers and Controlled Tool Advancement

The USPTO granted patent US12599443B2 to Globus Medical, Inc. covering surgical robotic automation with tracking markers and controlled tool advancement for implant insertion procedures. The patent includes 20 claims relating to threaded guide tubes for robotic surgical instruments and a dilator system enabling independent tool control within robotic surgical procedures.

Qatar University Surgical Robot Patent US12599442B2 Granted

USPTO granted Patent US12599442B2 to Qatar University on April 14, 2026, for an assistive surgical robot system for distal hole localization in intramedullary nail surgery. The patent covers a system including an imaging device, probe, robot, and computer program instructions for aligning fasteners to holes in implanted devices. The patent includes 18 claims and names three inventors.

Surgical Torque Sensor With Decision Support, Mazor Robotics

USPTO granted patent US12599441B2 to Mazor Robotics Ltd. on April 14, 2026. The patent covers a surgical system with a torque sensor for measuring power tool torque characteristics and decision support functionality. The 20-claim patent includes processors and memory for evaluating torque data and executing predetermined actions.

Multimodal Soft Tissue Imaging for Dermal Lesions

The USPTO granted patent US12599299B2 to Dentsply Sirona Inc. on April 14, 2026. The patent covers a method and device for multimodal imaging of dermal and mucosal lesions using at least two imaging modalities, including 3D scanning, with information on distance and angulation between the scanning device and the tissue. The patent contains 28 claims.

Systems and Methods for Detecting Physical Contact of Surgical Instrument with Patient Tissue

USPTO granted patent US12599298B2 to Intuitive Surgical Operations, Inc. on April 14, 2026. The patent covers a tissue contact detection system that monitors surgical instrument temperature during procedures to detect physical contact with patient tissue and trigger mitigation operations. The patent lists three inventors: Jonathan D. Halderman, Kayla K. Anderson, and Anqi Fan, with 17 claims covering the technology.

Apparatus for Cleaning a Laparoscope

USPTO granted US patent 12599297B2 to King Saud University for an apparatus designed to clean laparoscopes. The device includes a housing, fluid-moving assembly, wiping assembly, and trigger mechanism to spray cleaning fluid and wipe the transparent portion of the laparoscope housing. The patent contains 7 claims.

Medical Light Source Device and Medical Observation System

USPTO granted Patent US12599296B2 to Sony Olympus Medical Solutions Inc. on April 14, 2026, for a medical light source device featuring dual light sources—a laser emitter and measurement light source for monitoring light guide connection states—and a control system that adjusts laser output based on return light analysis. The patent contains 20 claims.

ODH Advises Diet and Exercise Changes to Cut Chronic Disease and Cancer Risk

The Ohio Department of Health issued a public health advisory recommending dietary and exercise changes to reduce chronic disease and cancer risk among Ohioans. ODH Director Dr. Bruce Vanderhoff advised increasing fiber intake, reducing sugar consumption, and engaging in at least 2.5 hours of weekly cardiovascular activity. Dr. Earl Thompson IV highlighted colorectal cancer screening importance, noting approximately 5,500 new cases and 2,000 deaths annually in Ohio.

New Interactive Dashboard Displays Ohio Kindergarten Immunization Data

The Ohio Department of Health announced the launch of a new interactive dashboard displaying kindergarten immunization data on the state DataOhio Portal. The dashboard provides current vaccine rates, exemption rates, and specific vaccine information (MMR, DTaP) by county, school, and across years from 2017-2018 to 2025-26. The dashboard supports informed decision-making by school officials, parents, and policymakers to help protect children from vaccine-preventable diseases.

Intraocular Lens Podeye Safety Notice - Field Safety Notice R2610293

ANSM has informed health establishments of a safety action implemented by the company Physiol/BVI regarding Podeye intraocular lenses. The safety action is registered under reference number R2610293. Health establishments concerned by this action should review the attached letter from Physiol/BVI dated 14/04/2026.

Inova Diagnostics Aptiva CTD Essential Controls Safety Action

ANSM published safety alert R2608798 informing medical biology laboratories of a quality control recall by Inova Diagnostics for Aptiva CTD Essential Controls used in autoimmune testing. The manufacturer's safety action letter was distributed to affected users on 14 April 2026. Laboratories should review the recalled controls and contact Inova Diagnostics directly for guidance.

Treating Glioblastoma Using Integrin Pathway Targeting

USPTO granted patent US12601743B2 to The Regents of the University of California for methods of treating drug-resistant glioblastoma (GBM) by targeting the integrin avb3 pathway. The patent covers diagnostic methods to determine tumor sensitivity and treatment methods for tumors identified as avb3+ and Glut3+ with specific molecular signatures. The patent contains 9 claims.

Maize Gene KRN2 and Uses Thereof Patent Grant US12600976B2

The USPTO granted Patent US12600976B2 to China Agricultural University for KRN2 gene technology controlling kernel row number in maize plants and associated molecular markers for molecular breeding applications. The patent contains 6 claims and names six inventors including Xiaohong Yang, Jiansheng Li, Wenkang Chen, Xuan Zhang, Lichun Cai, and Yirong Zhang.

Biomarker Combinations for NASH and Hepatic Fibrosis Diagnosis

USPTO granted patent US12601747B2 to Bio-Rad Laboratories for biomarker combinations used to diagnose Non-Alcoholic Steatohepatitis (NASH) and hepatic fibrosis status. The patent covers methods and kits for evaluating liver conditions based on three or more biomarker levels in subjects with NAFLD or NASH.

National Nutrition Committee Holds Fourth Meeting in Riyadh

The National Nutrition Committee held its fourth meeting of the third session at SFDA headquarters in Riyadh, chaired by SFDA CEO H.E. Dr. Hisham S. Aljadhey. The Committee reviewed its strategic performance report covering initiatives, projects, and achievements through Q1 2026, as well as the Saudi Food Composition Tables book developed under the Nutrient Content of Foods initiative. The meeting included representatives from various government and private sector entities.

Glaukos Ocular Drug Delivery Implant with Controlled Release

USPTO granted patent US12599497B2 to Glaukos Corporation on April 14, 2026, for an ocular drug delivery device with controlled drug release capabilities. The patent covers devices for treating ocular disorders through targeted administration of drugs to interior portions of the eye, with structures allowing treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber.

US12599499B2 - Devices and Methods for Creating a Capsulorhexis

USPTO granted Patent US12599499B2 to inventor Michael Schaller for devices and methods used in creating a capsulorhexis, a surgical procedure on the eye's capsular bag. The patent covers a template with a tearing profile, rigid and bendable sections for transitioning between insertion and use configurations, and connecting elements for manipulating the device during surgery. The patent contains 15 claims.

Heated Goggle Lens Patent US12599503B2

The USPTO granted patent US12599503B2 to UVEX ARBEITSSCHUTZ GMBH for a heated goggle lens comprising a main body with at least one transparent, electrically conductive coating and electrical contact means forming heating zones. The patent, filed January 21, 2022, contains 8 claims.

Medi USA LP Compression Garment Patent US12599505B2

USPTO granted Patent US12599505B2 to Medi USA, L.P. for a compression garment designed to provide compression to body parts, particularly limbs. The garment features a tubular padded sleeve with inner and outer layers secured together to form enclosures containing plastic foam particles. The patent includes 18 claims and was filed on June 13, 2022.

Wound Dressing Fluid Management Patent B2

USPTO granted patent US12599504B2 to Solventum Intellectual Properties Company for a wound dressing with fluid management technology. The patent covers a multi-layer dressing system including an evaporative film layer with high moisture vapor transfer rate, a carrier film layer with holes for evaporation, a superabsorbent layer, and a wicking layer for wound fluid management. The patent was filed November 19, 2019, under application 17294580 with 13 claims.

US12599502B2 - Ophthalmic Laser Surgical System with Bubble Shield for Reducing Retinal Radiation Exposure

USPTO granted patent US12599502B2 to Alcon Inc. (inventor: Zsolt Bor) for an ophthalmic laser surgical system that reduces retinal radiation exposure during floater treatment. The system uses a three-dimensional pulse pattern with a bubble shield pulse at the posterior side to form a protective bubble shield over the retina. The patent (CPC: A61F 9/008) contains 9 claims and was filed October 25, 2022.

Patent US12599500B2 for Ophthalmological Surgical Instrument

USPTO granted patent US12599500B2 to Università degli Studi di Cagliari on April 14, 2026, covering an ophthalmological surgical instrument with a hollow oblong body and cutting assembly featuring pivotally hinged arms, toothed rack, and pinion gear mechanism. The patent contains 14 claims and provides intellectual property protection for the medical device design.

Automated Image Guidance System for Ophthalmic Surgery

The USPTO granted Patent US12599498B2 to Alcon Inc. covering an automated image guidance system for ophthalmic surgery. The system automatically initializes image-guided surgery by detecting a user's eye in captured images, initiating a registration procedure, and generating overlay content for presentation via a second imaging device. The patent contains 20 claims.

Method for Making Elastomeric Laminates

Procter & Gamble Patent, Elastomeric Laminate Manufacturing Method

Apparatus and Method for Intra-Cardiac Mapping and Ablation

USPTO granted patent US12599433B2 to Kardium Inc. on April 14, 2026, covering an intra-cardiac mapping system that uses convective cooling effects of blood flow to locate heart chambers for ablation procedures to treat atrial fibrillation. The patent describes a catheter-deployed expandable net or scanning catheter that performs both cardiac mapping and ablation. The patent contains 35 claims with inventors Daniel Gelbart and Samuel Victor Lichtenstein.

Sirona Medical Catheter With Improved Irrigation - US12599431B2

USPTO granted Patent US12599431B2 to Sirona Medical Technologies, Inc. for a catheter with expandable and contractible fluid pathways. The invention includes an elongate body with a distal electrode, expandable members between the electrode and body distal end, an actuator for advancing and retracting the electrode, and a fluid-sealed lumen configured to expand and collapse with electrode movement. The patent contains 17 claims and covers catheters with improved irrigation capabilities for medical procedures.

Adjustable Marker Reference Device for Surgery (US12599440B2)

USPTO granted Patent US12599440B2 to Point Robotics Medtech Inc. for an adjustable marker reference device used to identify surgical instruments. The patent covers a device with a base, upper cover, connecting rods, markers, and a fixing button mechanism that allows controlled movement and positioning of markers for surgical navigation.

Lung Tissue Navigation System

USPTO granted patent US12599439B2 to Covidien LP on April 14, 2026, for a system and method of navigating to target sites in lung tissue using an extended working channel with electromagnetic sensors integrated into an electromagnetic navigation system. The patent contains 20 claims and covers technology for determining and displaying the distance from a tool to a target site on a display device.

Stent End Point Locations System

USPTO granted Koninklijke Philips N.V. Patent US12599438B2 for a system and method for determining suitable end point locations for a stent using intraluminal imaging. The system includes processors configured to receive temporal sequences of intraluminal images from an imaging device and identify whether positions along a lumen represent suitable stent end points. The patent contains 19 claims.

Pre-Procedure Planning, Intra-Procedure Guidance for Biopsy and Ablation

USPTO granted Patent US12599437B2 to Covidien LP covering a system and method for navigation of a luminal network for pre-procedure planning and intra-procedure guidance during biopsy and ablation of tumors. The system uses CT image data, generates 3D models, and provides real-time catheter sensor location registration for navigation to tumors. The patent includes 20 claims and covers technology for use with or without cone-beam CT or fluoroscopic imaging.

Boston Scientific Patent US12599435B2 for Catheter Ablation Using Irreversible Electroporation

USPTO granted patent US12599435B2 to Boston Scientific Scimed, Inc. on April 14, 2026, for catheter systems and methods using pulsed DC voltage to drive irreversible electroporation for selective tissue ablation. The patent includes claims covering voltage pulse generators, electrode controllers with selection and pulse delivery modules, and methods for delivering pulsed voltage waveforms to selected electrodes.

Devices, Systems and Methods for Treatment of Abnormal Tissue Using Pulsed Electric Fields

USPTO granted Patent US12599432B2 to Galvanize Therapeutics, Inc. for devices, systems, and methods to treat abnormal tissue using pulsed electric field (PEF) energy. The patent covers non-thermal energy delivery that preserves extracellular matrices, blood vessels, and lymphatics while treating tumors, cysts, or diseased tissue. The 26 claims span filing date October 15, 2021, under application number 17502640.

Perivascular Nerve Denervation Catheter Patent US12599430B2

USPTO granted patent US12599430B2 to Deepqure Inc. on April 14, 2026. The patent covers a perivascular nerve denervation catheter featuring a shaft with a distal loop configured to curl around tissue and a plurality of electrodes made of two-way shape-memory alloy. The application was filed March 2, 2021, and includes 12 claims.

Methods for Controlling Treatment Volumes in Pulsed Electric Field Treatments

USPTO granted Patent US12599429B2 to North Carolina State University covering methods for electrotherapy via pulsed electric field. The patent describes modifying or killing target cells while simultaneously controlling treatment volumes, thermal gradients, muscle stimulation, and immune responses through dynamically adjusted electrical pulse delivery profiles. The patent contains 20 claims.

SG LLC Lateral Disc Replacement Implant Patent US12599487B2 Granted

USPTO granted patent US12599487B2 to SG LLC for a lateral disc replacement implant including first and second endplates, a core between the endplates, and an annulus surrounding the core. Inventors: Paul Glazer and Michael J. Milella, Jr. Application filed July 13, 2023.

Bi-Planar Expandable Spine Cage Patent US12599488B2

USPTO granted patent US12599488B2 to HILO INNOVATIONS, LLC for a bi-planar expandable spinal cage featuring separate sagittal and coronal balance control units. The invention allows independent adjustment of spacing distance and gradient between upper and lower structural bodies. The patent includes 7 claims and covers CPC classifications A61F 2/447 and A61F 2002/443.

Spinal Cage Bone Screw Fixation, Patent US12599489B2, 14th Apr

The USPTO granted Patent US12599489B2 to GBS Commonwealth Co., Ltd. on April 14, 2026, covering a spinal cage fixable through bone screw insertion. The invention includes a cage body with a receiver having multiple screw holes, and a fixture that moves outward during screw insertion and inward after completion to prevent screw separation. The patent contains 8 claims.

Uncaging Stent Patent US12599490B2 - Elixir Medical

The USPTO granted Patent US12599490B2 to Elixir Medical Corporation for an uncaging stent technology. The patent covers a stent or luminal prosthesis with circumferential structural elements that provide high strength after deployment and allow for scaffold uncaging and luminal expansion. The patent includes 27 claims and was filed on March 3, 2023.

Biliary Stent Patent US12599491B2 Granted to BVW Holding AG

USPTO granted Patent US12599491B2 to BVW Holding AG for a biliary stent endoprosthesis featuring a polymeric coating with micropattern surface textures. The patent covers stents with inner/outer surfaces, lumens, and macropattern surface features in both expanded and contracted states. The patent includes 20 claims and names Lukas Bluecher and Michael Milbocker as inventors.

Axially Compressible Bare Stent with Overlapping Wires for Aortic Treatment

USPTO granted Patent US12599492B2 to Shanghai Flowdynamics Medical Technology Co., Ltd. for an axially compressible bare stent used in aortic aneurysm and dissection treatment. The stent is formed by interleaving two wires of different diameters (20-150 μm and 150-600 μm) to achieve at least 30% metal coverage with strong radial support. Inventors are Jian Ding and Chenying Fan. The patent includes 16 claims.

Method of Deploying Intraluminal Device to Cardiac Stomach Region with Endoscopic-Laparoscopic System

USPTO granted patent US12599493B2 to BFKW, LLC for a method of deploying an intraluminal device to the cardiac region of the stomach. The invention involves trans-oral endoscopic deployment of the device with retention against the cardiac region while being fastened laparoscopically from the abdominal cavity with concurrent endoscopic visualization. The patent includes 18 claims covering both the method and the intraluminal system.

Force Redistribution Hindfoot Shoe Insert

The USPTO granted patent US12599494B2 to ROXILLA LLC for a force redistribution hindfoot shoe insert designed to absorb shock and redistribute forces within a user's foot and/or knee. The device includes a hindfoot insert portion with a fascia projection positioned medially between the sides and a lateral projection on the lateral side. The patent contains 22 claims and was filed on April 5, 2023.

Male External Catheter with Attachment Interface Configured to Bias Against Penis

USPTO granted Patent US12599495B2 to PUREWICK CORPORATION for a male urine collection device. The patent covers a receptacle for collecting urine with movable flaps configured to bias against the penis, and a clamshell design with two halves connected by a hinge for secure attachment. The filing date was December 23, 2021, with Application No. 17645821 and 17 claims.

Physio Tape With Inductive Heating System

The USPTO granted patent US12599496B1 to inventor Jason Fladoos for an inductive heating system integrated into physio tape. The invention includes plural pockets along the tape length housing removable heating or cooling elements, with at least one being an inductive heating element adapted to receive magnetic energy from a remote inductive heating source. The patent contains 11 claims.

Electrosurgical Generator Having Extended Measurement Range Patent

USPTO granted patent US12599426B2 to Olympus Winter & Ibe GmbH for an electrosurgical generator with a configurable measurement system. The invention allows switching between different measurement configurations during operation to maintain accuracy across high and low amplitude signals. The patent includes 17 claims.

Energy Treatment Tool and Treatment System - US12599428B2

USPTO granted Patent US12599428B2 to Olympus Corporation on April 14, 2026. The patent covers an energy treatment tool with a grip, lever mechanism, electric switch, and rotatable driver for switching between contacting and noncontacting states. The invention, filed July 20, 2021 (Application No. 17380868), contains 19 claims under CPC classifications A61B 18/1447 and related A61B subclasses.

Smog Suction Structure for Electrosurgical Handpiece

USPTO granted Patent US12599427B2 to inventor In-Sang Choi for a smog suction structure designed for electrosurgical handpieces. The invention efficiently removes surgical smog that obstructs the operating surgeon's view and poses health hazards. The patent, filed on December 3, 2020, includes 7 claims and is classified under CPC codes related to electrosurgical instruments and suction devices.

Perivascular Denervation Catheter Patent Grant to DEEPQURE INC.

The USPTO granted patent US12599425B2 to DEEPQURE INC. on April 14, 2026. The patent covers a perivascular denervation catheter featuring a shaft with a loop disposed near the distal end, configured to curl around tissue and deliver energy for nerve ablation. The loop includes a bendable film, parallel electrodes, and sensors positioned between electrode pairs. The patent contains 13 claims.

Cryogenic Catheter Probe for Gastrointestinal Tract Ablation

The USPTO granted patent US12599424B2 to Agil Therapeutics, Inc. on April 14, 2026. The patent covers a cryogenic catheter probe, system, and method for selective ablation of mucosal and submucosal tissue in the gastrointestinal tract. The invention includes a chamber with a central rail, cryogenic fluid delivery channels, and a sprayer configured to release cryogenic spray in treatment zones along the chamber. The patent contains 17 claims.

Apparatus for Pressing Out Bone Cement, Use and System

USPTO granted patent US12599423B2 to Heraeus Medical GmbH on April 14, 2026. The patent covers an apparatus for pressing out bone cement from a cartridge, featuring a threaded rod with external thread, a handle for rotating the threaded rod, and an adapter unit with internal thread. The outer surface of a thread turn of the external thread is not more than 370 mm2. The patent includes 15 claims and was filed on October 21, 2024.

Sacral Tether Anchor Spinal Implant Patent Granted

The USPTO granted patent US12599421B2 to Empirical Spine, Inc. on April 14, 2026, covering a sacral tether anchor spinal implant system. The patent covers a constraint device with a tether structure and compliance member adapted to couple with a superior spinous process and sacrum, along with an anchor member anchored to the sacrum. Inventors include Todd Alamin, Louis Fielding, Darin Gittings, Hugues Malandain, Anand Parikh, Eller Torres, and Ian Bennett. Medical device manufacturers and competitors in the spinal implant sector should monitor this patent when developing or designing spinal correction and restriction devices. The patent may restrict freedom to operate for similar sacral tether and spinous process constraint systems in the US market.

Shiga University Surgical Instrument Patent for Coracoid Process and Scapular Neck Movement

The USPTO granted patent US12599420B2 to National University Corporation Shiga University of Medical Science for a surgical instrument designed to facilitate proximity between the coracoid process and scapular neck. The instrument includes a shaft extending in a first direction and an inclined part extending at an angle of 95° to 115° to the first direction, with a notch for screw passage. The patent contains 10 claims and was filed on July 6, 2021.

Beveled Screw - US12599419B2 - Tyber Medical LLC

USPTO granted Patent US12599419B2 to Tyber Medical LLC on April 14, 2026. The patent covers a beveled screw design featuring a screw head with a bevel, an elongate shaft with a central longitudinal axis, and a tip distal from the head, for implantation into bone or bone fragments. The patent includes 13 claims and covers both the device and associated implantation methods.

Bone Fixation Device with Porous Architecture for Bone Ingrowth

USPTO granted Patent US12599418B2 to Paragon Advanced Technologies, Inc. for a bone fixation device featuring a plate portion and a bone wedge portion with porous architecture designed to promote bone ingrowth for fusion and osteosynthesis of bone segments. The patent includes 20 claims and covers the device, manufacturing method, and fixation kit.

Electronic Prior Authorization Requirements for Medicare Advantage Medicaid CHIP QHP Issuers

CMS published a proposed rule (CMS-0062-P) requiring Medicare Advantage organizations, state Medicaid and CHIP fee-for-service programs, Medicaid managed care plans, CHIP managed care entities, and Qualified Health Plan issuers on the Federally-facilitated Exchanges to implement electronic prior authorization for drugs and extend existing interoperability requirements to drugs. The rule would also require impacted payers to report API endpoints to CMS, adopt HL7 FHIR standards as HIPAA transaction standards, and would establish a definition for "failure to report" enabling civil monetary penalties for applicable manufacturers or GPOs that fail to grant CMS timely access for audits. Comments are due June 15, 2026.

Medicare HCPCS Level II Public Meeting

CMS announces the first biannual 2026 HCPCS Level II public meeting to discuss preliminary coding, Medicare benefit category, and payment determinations for new non-drug and non-biological items and services. The primary meeting is scheduled for June 1, 2026 in Baltimore, MD, with an overflow virtual session on June 2, 2026. Speaker registration closes May 18, 2026, and written comments are due June 3, 2026.

Merit Medical Recalls 16F Dual-Valved Splittable Sheath Introducer

Merit Medical is recalling the 16F Dual-Valved Splittable Sheath Introducer, a component used in several dialysis catheter kits, due to a design defect where the sheath introducer may not split as intended. The FDA has classified this as a Class I recall, the most serious type. Healthcare providers are advised to immediately stop using, apply recall stickers to, and destroy affected devices. Two serious injuries have been reported as of February 23, 2026, with no deaths associated with this issue.

Treasury Proposes Whistleblower Rewards for Reporting Healthcare Fraud

FinCEN released a proposed rule on March 30, 2026, to establish a new whistleblower reward program targeting financial crimes including fraud against government healthcare plans. Qualifying whistleblowers may receive 10 to 30 percent of funds recovered when enforcement penalties exceed $1 million. The program excludes certain employees involved in compliance, audit, or internal reporting processes from bounty eligibility unless 120 days pass without corrective action.

Virginia Senate Bill 170 and House Bill 627 Restrict Noncompete Agreements

Virginia has enacted SB 170 and HB 627, landmark legislation restricting covenants not to compete. SB 170 requires employers to provide severance benefits for noncompetes to be enforceable when terminating employees without cause, with civil penalties of $10,000 per violation. HB 627 categorically prohibits noncompetes with health care professionals licensed by the Board of Medicine, Nursing, Counseling, Optometry, Psychology, or Social Work, with an exception only for sale-of-business scenarios. The laws apply to all agreements entered, amended, or renewed on or after July 1, 2026.

EPA Draft CCL 6 Identifies Microplastics and Pharmaceuticals as Priority Drinking Water Contaminants

The EPA published its draft Sixth Contaminant Candidate List (CCL 6) on April 2, 2026, identifying microplastics and pharmaceuticals as priority contaminant groups for potential future drinking water regulation under the Safe Drinking Water Act. The draft also includes PFAS, disinfection byproducts, 75 individual chemicals, and nine microbes. EPA announced human health benchmarks for 374 pharmaceuticals. The draft CCL 6 is a procedural screening step that does not itself establish enforceable standards or require immediate action by water systems or industry.

CD38 Antibody Variant Improves Manufacturing Yield

USPTO granted patent US12600790B2 to Vivasor, Inc. covering a variant anti-CD38 IgG antibody with improved manufacturing yield and a mutated light chain that reduces cleavage heterogeneity. The patent contains 19 claims and is classified under C07K 16/2878 and related CPC codes.

Single-Domain Antibodies That Bind ROR1

USPTO granted Patent US12600801B2 to Fred Hutchinson Cancer Center for single-domain antibodies binding receptor tyrosine kinase ROR1. The patent covers anti-cancer therapeutics, antibody-drug conjugates, multi-domain binding molecules, and cancer imaging/diagnostic agents. The patent contains 20 claims with inventors Jason Price, Colin E. Correnti, and James M. Olson.

Anti-IgG Nanobodies Patent Granted to Max-Planck

USPTO granted patent US12600799B2 to Max-Planck-Gesellschaft on April 14, 2026 for novel anti-IgG nanobodies directed against rabbit or mouse IgG. The patent contains 11 claims classified under CPC C07K 16/42. The invention also covers methods for producing and using said nanobodies.

5T4 Binding Polypeptides for Cancer Therapy

USPTO granted patent US12600794B2 to Abdera Therapeutics for 5T4 binding polypeptides useful for cancer therapy. The 36 claims cover polypeptides conjugated to chelating agents or radionuclide complexes. The patent protects compositions and methods for treating 5T4-expressing cancers.

IGF-1R Antibodies With Extended Half-Lives for Thyroid Eye Disease Treatment

USPTO granted US Patent US12600788B2 to Viridian Therapeutics, Inc. covering antibodies and compositions targeting Insulin-Like Growth Factor-1 Receptor (IGF-1R) with extended half-lives for treating thyroid eye disease. The patent contains 18 claims and names six inventors including Vahe Bedian, Peter Harwin, and Jonathan Violin.

Artificial Eye Lens with Cavity Design for Reduced Incision Implantation - US12599477B2

USPTO granted patent US12599477B2 to Carl Zeiss Meditec AG for an artificial eye lens with front and rear lens elements connected by an intermediate element forming a cavity with an opening for liquid flow. The design allows reduction of the access incision necessary for implantation. The patent includes 15 claims and covers methods for production and implantation of the lens.

US12599486B2 - Glenoid Implant Pin Placement Instrument with Patient Specific Instrumentation

USPTO granted patent US12599486B2 for a pin placement instrument used in glenoid implant surgery. The instrument features an anatomical interface with a hook-like portion for receiving bone in a planned position, a drill guide with lateral-opening slots, and a removably placeable bushing for pin placement. The patent was filed August 3, 2022, under application number 17880302, with 7 claims.

Polishing Device for Orthopedic Devices Patent Granted

USPTO granted Patent US12599484B1 to Spartan Felt Company, Inc. on April 14, 2026. The patent covers a polishing device for orthopedic implants, including acetabular cups. The device features a compressible polishing head with rounded surfaces for polishing concave surfaces, made from impregnated felt materials. The patent contains 8 claims and was filed on July 9, 2021.

US12599483B2 Boney Structure Joining Patent Grant

USPTO granted patent US12599483B2 to Randall F. Lee for systems and methods to join boney structures. The invention uses at least one non-threaded anchor and an implant with apertures, where the anchor head interacts with the implant aperture to cause transverse movement for compression or distraction of coupled boney structures. The patent has 7 claims.

Transcatheter Mitral Valve Regurgitation Coaptation Device with Secondary Anchors

USPTO granted Patent US12599482B2 to Polares Medical Inc. for a transcatheter mitral valve regurgitation coaptation device with secondary anchors. The patent covers a coaptation assistance element, delivery catheter, and implantation method with 20 claims.

Systems and Methods for Prosthetic Heart Valve Delivery

USPTO granted Patent US12599481B2 to 4C Medical Technologies, Inc. for delivery systems and methods for implanting prosthetic heart valves. The patent covers technology for delivering self-expanding prosthetic mitral valve devices to the left atrium without engagement of the left ventricle or native mitral valve leaflets. The patent contains 16 claims and was filed on November 8, 2023.

Edwards Lifesciences Percutaneous Mitral Valve Replacement Patent B2

The USPTO granted patent US12599480B2 to Edwards Lifesciences Corporation for a percutaneous mitral valve replacement device. The prosthetic heart valve includes an outer frame with atrial flange, an inner frame, and a valve structure with leaflets, designed to match the patient's native mitral valve anatomy. The patent contains 10 claims and was filed on November 15, 2023.

Heart Valve Crown Piece with Leaflets, Top Cuff, and Bottom Cuff Patent

USPTO granted Patent US12599479B2 to Venus Medtech (Hangzhou), Inc. for a heart valve comprising a crown piece interconnected to leaflets, a top cuff, and a bottom cuff. The invention includes ring-shaped crown piece, top cuff, and bottom cuff components designed for interconnection with medical implant frames. The patent contains 16 claims and covers the structural configuration of transcatheter heart valve assemblies.

DONGBANG MEDICAL Rhinoplasty Suture Patent Granted

USPTO granted patent US12599478B2 to DONGBANG MEDICAL CO., LTD. for a lifting suture for rhinoplasty and manufacturing method. The patent covers a device with cogs formed in first and second regions connected by a pressed connecting region. Application 18382060 was filed October 20, 2023, with 5 claims.

Spinal Brace Rod Patent US12599411B2 Granted to Globeride, Inc.

The USPTO granted patent US12599411B2 to Globeride, Inc. on April 14, 2026, for a fixture rod for spinal braces featuring a core member and reinforcing fiber layer. The patent, filed September 10, 2021 (Application No. 18027818), contains 8 claims and addresses high rigidity and durability against deformation loads.

Smart Spinal Implant Sensors Patent Granted to Warsaw Orthopedic

The USPTO granted Patent US12599412B2 to Warsaw Orthopedic, Inc. covering smart spinal implant sensors with measurement capabilities for spinal constructs. The patent includes method claims for attaching sensor-equipped implants to spinal constructs and performing intra-operative adjustments based on received sensor data.

CarboFix Spine Composite Spinal Implant US12599413B2

The USPTO granted patent US12599413B2 to CarboFix Spine Inc. for a composite material spinal implant construct kit. The patent covers pedicle screw technology with an embracing structure and upper fastener having polygonal profile. The application was filed March 9, 2020, under application number 17437072, and includes 20 claims.

Bone Anchoring Device with Receiving Part for Rod Coupling

USPTO granted patent US12599414B2 to Biedermann Technologies GmbH & Co. KG for a bone anchoring device receiving part. The device includes a receiving body with a rod-receiving channel and accommodation space, plus a pressure element with a flexible portion for clamping a bone anchoring element head. The pressure element moves along the receiving part's longitudinal axis from an inserting position through pre-locking to a final locking position.

NuVasive Adjustable Implant Patent US12599416B2 Granted

USPTO granted patent US12599416B2 to NuVasive Specialized Orthopedics, Inc. on April 14, 2026. The patent covers an adjustable implant including a housing, a first adjustable member positioned within the housing and moveable relative to the housing, and a first actuation assembly configured to move the first adjustable member relative to the housing. The patent contains 18 claims and is classified under CPC A61B 17/7016 and related surgical device categories.

Patella Bone Plate System

The USPTO granted Patent US12599417B2 to Smith & Nephew, Inc. on April 14, 2026, covering patella bone plate systems for surgical reconstruction. The patent claims a contoured body with arms, variable angle holes, locking and fixation holes, slots, and a hook design extending around the patella apex. The 19 claims establish enforceable intellectual property rights for the assignee.

System and Method to Measure Uterine Wall Thickness - Cilag GmbH

USPTO granted patent US12599407B2 to Cilag GmbH International for a system to measure uterine wall thickness. The system includes a control console, laparoscopic instrument, and uterine manipulator with proximity sensors that cooperatively measure distance between instruments and generate alerts when distances fall below threshold values.

Bearing Assemblies for Selectively Coupling Surgical Instrument Components

USPTO granted patent US12599408B2 to Medos International Sàrl covering bearing assemblies for selectively coupling surgical instrument components. The patent includes 20 claims for assemblies with a housing, translating first race, bearing elements, and fixed second race configured to selectively lock to surgical instruments. Filing date was December 14, 2023.

Hinge for External Bone Fixator - Advanced Trauma Solutions

USPTO granted patent US12599409B2 to Advanced Trauma Solutions LLC for a hinge apparatus used in external bone fixators. The invention includes outrigger bars, joint bodies, a torque amplifying knob with collapsible turn levers, and a screw turn actuator. The patent has 14 claims and 3 CPC classifications in the A61B medical device category.

Multi-Clamp Surgical Device for External Bone Fixator

USPTO granted patent US12599410B2 to Advanced Trauma Solutions, LLC covering a multi-clamp apparatus for orthopedic external bone fixators. The invention features two clamp arms with opposing crescentic channels for securing multiple bone pins, collapsible torque amplifying knobs for hand operation, and ergonomically designed turn levers. The patent contains 20 claims.

NCHS Data Detectives Camp, Comments Due Jun 14

CDC's National Center for Health Statistics (NCHS) is seeking public comments on the NCHS Data Detectives Camp educational program. The program is designed to educate students about health statistics and data analysis. Comments are due June 14.

TB Follow-up Worksheet, Newly-Arrived Deadline 14th Jun

CDC has published a TB Follow-up Worksheet for newly-arrived individuals with a compliance deadline of June 14th. The worksheet provides guidance for TB screening follow-up procedures for newly-arrived populations. Healthcare providers and public health authorities conducting TB screening should utilize this document for compliance purposes.

Federal Register Daily Issue, 14th Apr

The Federal Register published its daily issue on April 14, 2026, containing 112 documents from 38 agencies across 1006 pages. The issue includes 95 Notices, 8 Proposed Rules, and 9 Rules, along with 3 Significant Documents. This table of contents provides access to documents from agencies including the Air Force Department, Centers for Disease Control and Prevention, and Agriculture Department.

National Heart, Lung, and Blood Institute Notice of Meeting

The National Heart, Lung, and Blood Institute (NHLBI), part of the NIH, published a Federal Register Notice on April 14, 2026 announcing a public meeting scheduled for May 26, 2026. This notice satisfies requirements under the Federal Advisory Committee Act for public disclosure of advisory committee meetings. No regulatory obligations or compliance deadlines are established by this document.

National Institute of Dental and Craniofacial Research Notice of Closed Meeting

The National Institute of Dental and Craniofacial Research (NIDCR) has issued a notice announcing a closed advisory council meeting scheduled for May 27-28, 2026. The meeting is closed to the public as it will involve discussion of grant applications and other privileged or predecisional matters. This is a routine administrative announcement.

Prospective Grant of Exclusive Patent License: Catheter-Based Myotomy Devices And Systems

The National Institutes of Health (NIH) has published a notice of prospective grant of exclusive patent license to Septune for catheter-based myotomy devices and systems. The NIH is seeking public comments on this prospective license agreement. The comment period closes on May 14, 2026.

Draft Guidance on Safety Assessment of Genome Editing Using Next-Generation Sequencing

The FDA's Center for Biologics Evaluation and Research issued draft guidance recommending next-generation sequencing methods for assessing off-target editing risks and genome integrity in human gene therapy products using genome editing technologies. The guidance applies to both ex vivo and in vivo products and provides recommendations on sequencing strategies, sample selection, analysis parameters, and reporting. Sponsors submitting investigational new drug applications or Biologics License Applications for genome editing therapies should incorporate these safety assessment methods into nonclinical studies. The FDA is accepting public comments for 90 days.

Tubular Mesh Support Device for Breast Implant - Patent Grant US12599474B2

The USPTO granted patent US12599474B2 to Novus Scientific AB for a tubular mesh support device designed for breast implant applications. The patent, filed May 6, 2020, was granted on April 14, 2026 and contains 9 claims covering the mesh support device and methods for preparing breast implants for human implantation.

Accommodating Intraocular Lenses and Methods of Manufacturing

The USPTO granted Alcon Inc. Patent US12599475B2 for accommodating intraocular lens technology. The patent covers an optic body with a radially extending projection featuring a flat haptic contact surface, with the haptic secured via a butt joint and including a fluid chamber. Six claims were issued.

Vascular Device Marker Attachment

USPTO granted Patent US12599458B2 to Covidien LP on April 14, 2026. The patent covers a thrombectomy device with an arcuate marker-mounting projection where the marker contacts the projection at three discrete locations. The device is designed to expand from a first configuration to a second configuration for engaging blood clots in vessels.

Biliary Stent Implant US12599468B2

USPTO granted patent US12599468B2 to ENDO GI MEDICAL LTD for an apparatus for deploying multiple biliary stents. The invention includes a guide tube with a slit and sequentially deployable stents for treating biliary duct obstructions.

Expandable Stent Devices for Blood Flow Passage Treatment

USPTO granted patent US12599471B2 to The Foundry, LLC for expandable stent devices designed to treat blood flow passages. The patent covers stents with a collapsed delivery configuration and an expanded configuration, featuring struts and longitudinally extending spines configured to move in opposing axial directions during expansion. The patent application was filed on March 24, 2021, and the grant includes 32 claims.

Tensionable Knotless Tissue Repair Systems and Surgical Methods Patent Granted

USPTO granted patent US12599473B2 to Arthrex, Inc. on April 14, 2026. The patent covers tensionable knotless tissue repair systems and methods using soft suture staple assemblies and knotless suture anchors for reducing and fixating tissue to bone. The patent contains 19 claims.

Covered Stent with Elastic Supporting Member and Imaging Member

The USPTO granted Patent US12599472B2 to Lifetech Scientific (CO.), LTD. for a covered stent invention. The device comprises a hollow tubular main body with a window on its side wall, an elastic supporting member at the window periphery, and an imaging member movably connected to the supporting member. The patent contains 9 claims.

LAG-3 Antibody Combination Therapies - Patent US12600777B2

The USPTO granted patent US12600777B2 to Novartis AG covering combination therapies comprising antibody molecules that specifically bind to LAG-3. The patent contains seven claims and relates to methods for treating, preventing, and/or diagnosing cancerous or infectious disorders. This represents a grant of exclusive intellectual property rights to Novartis AG for the therapeutic application of LAG-3 antibody combinations.

Tumor-Targeted Bispecific CD28 Antigen Binding Molecules Patent Grant

USPTO granted patent US12600781B2 to Hoffmann-La Roche Inc. covering tumor-targeted bispecific agonistic CD28 antigen binding molecules characterized by monovalent binding to CD28. The patent includes 51 claims covering the binding molecules, methods of production, pharmaceutical compositions containing these antibodies, and methods of using the same for cancer treatment.

RAGE Antibodies Patent Granted SUNY Apr 14

USPTO granted Patent US12600778B2 to The Research Foundation for The State University of New York for antibodies specific to the heparan sulfate binding site of Receptor for Advanced Glycation Endproducts (RAGE). The patent includes methods for treating conditions involving RAGE through antibody administration, with 4 claims allowed.

Method of Screening Compounds Inhibiting Pancreatic Cancer RNF43 Mutation

The USPTO granted Patent US12600785B2 to Antlera Therapeutics Inc. covering a method of screening compounds that inhibit proliferation of pancreatic cancer cells having a loss-of-function mutation in the RNF43 gene. The patent discloses FZD5-binding agents for treating diseases associated with aberrant Frizzled protein expression. The patent contains 5 claims and names Guohua Pan, Jason Moffat, Sachdev Sidhu, Stephane Angers, Zachary Steinhart, and Xiaowei Wang as inventors.

Novo Nordisk Patent for IL-6 Antagonist Treatment of Diuretic Resistant Heart Failure

The USPTO granted Patent US12600773B2 to Novo Nordisk A/S on April 14, 2026, covering methods of treating diuretic resistant heart failure patients carrying at least one copy of the TMPRSS6 rs855791 allele by administering an IL-6 antagonist. The patent also covers treatment of patients with elevated urine or plasma IL-6 levels requiring diuresis. The patent (CPC: C07K 16/248) names five inventors and issues from Application No. 17519082 filed November 4, 2021, with 10 claims granted.

AngioSafe Catheter - Device and Method for Centering and Crossing Vascular Occlusion

USPTO granted patent US12599398B2 to AngioSafe, Inc. for a catheter device designed to center and cross vascular occlusions. The invention includes a catheter body with central passage, rotatable drive shaft with cutting tip, and spiral springs for maintaining catheter centering through chronic total occlusions. The patent contains 19 claims.

Ultrasonic Treatment Instrument

USPTO granted patent US12599396B2 to Olympus Medical Systems Corp. for an ultrasonic treatment instrument. The patent includes 17 claims and covers a vibration transmitter with first and second supports and a tubular portion. Filing date was August 11, 2023.

Spinal Simplicity Surgical Kit Granted US12599400B1

USPTO granted patent US12599400B1 to Spinal Simplicity, LLC for a surgical kit used in spinal decompression procedures to treat spinal stenosis. The patent covers access instruments, bone reamers, and soft tissue removal instruments for both minimally invasive and open procedures targeting the interlaminar region of the lumbar spine.

Methods, Systems, and Devices for Surgical Access and Insertion

The USPTO granted Patent US12599403B2 to the Board of Regents of the University of Nebraska covering methods, systems, and devices for surgical access and insertion into insufflated patient cavities. The patent names Thomas Frederick, Shane Farritor, Jack Mondry, Eric Markvicka, Dmitry Oleynikov, and Jacob Greenburg as inventors and contains 20 claims.

Intraosseous Device Including Sensing Obturator

The USPTO granted Patent US12599405B2 to Bard Access Systems, Inc. covering an intraosseous access system with a driver, needle, and sensor-equipped obturator. The system detects modality changes via an electrical impedance sensor including a passive RFID chip. The patent contains 10 claims and covers the device's control logic that modifies driver operation upon detecting changes.

Boston Scientific Patent Granted: Tissue Puncturing Medical Device

The USPTO granted US Patent 12599406B2 to Boston Scientific Medical Device Limited on April 14, 2026. The patent covers a medical device for puncturing tissue featuring an elongate member with distal curved and straight portions, an active tip for energy delivery, and a constant diameter layer. The patent contains 13 claims.

Iowa HHS Announces Additional Funding to Fight Opioid Crisis

Iowa HHS announced additional opioid settlement funding availability through House File 1038 (2025), directing 75% of Iowa's opioid settlement money toward crisis response. $10 million is available per funding round with individual grants up to $1 million per project. Eligible activities include prevention, treatment, recovery services, and overdose reversal drug distribution.

CDC Agency Forms Undergoing Paperwork Reduction Act Review

CDC has submitted the information collection request "Poison Center Collaborations for Public Health Emergencies (PCCPHE)" to OMB for review under the Paperwork Reduction Act. The notice allows an additional 30 days for public comments following three comments received from the prior January 2026 notice. America's Poison Centers, a national network of 53 poison centers, serves as CDC's key partner for this surveillance initiative.

Environmental Public Health Training, April 15, 2026

The Indiana Department of Health announced a virtual Environmental Public Health Training scheduled for Wednesday, April 15, 2026 from 9:30am to 11:30am EDT. The event is hosted by IDOH's Local Health Department Program and is open for registration. This is one of ten scheduled training dates in the series.

US12600703B2 - Farnesyl Dibenzodiazepinone Synthesis Patent

USPTO granted patent US12600703B2 to AMO Pharma Ltd. covering methods of synthesizing farnesyl dibenzodiazepinone compounds, including AMO-01. The patent has 4 claims and was filed on May 28, 2021. Patent grants establish legally enforceable intellectual property rights for the disclosed chemical synthesis methods.

Low-Viscosity Hardener Manufacturing Method Patent

USPTO granted patent US12600706B2 to Nan Ya Plastics Corporation for a method of manufacturing low-viscosity hardener using isomerization of 3-methyltetrahydrophthalic anhydride and 4-methyltetrahydrophthalic anhydride. The patent covers a hardener crude product with a weight ratio of 3:7 to 7:3 between the two anhydrides, producing a final viscosity of 30-50 cps. The patent includes 8 claims and names Te-Chao Liao, Jung-Jen Chuang, Chung-Yu Chen, and Jung-Tsu Wu as inventors.

Gannex Pharma FXR Modulating Compound Patent US12600716B2

USPTO granted patent US12600716B2 to Gannex Pharma Co. Ltd. on April 14, 2026, for FXR-modulating compounds having a structure of formula (I), including pharmaceutically acceptable salts, esters, and stereoisomers. The patent contains 19 claims and covers therapeutic applications including liver disease (A61P 1/16), metabolic disorders, cardiovascular conditions, and kidney disease.

Boehringer Ingelheim Patent for sGC Activators in Systemic Sclerosis Treatment

The USPTO granted patent US12600715B2 to Boehringer Ingelheim International GmbH covering methods for treating systemic sclerosis using soluble guanylate cyclase (sGC) activators of formula (I) or their pharmaceutically acceptable salts. The patent names Mary Ruth Flack, Julia Kaufman, and Indra Sethy-Coraci as inventors and includes 20 claims spanning therapeutic applications including respiratory, dermatological, pain, and immunological indications. This method patent provides Boehringer Ingelheim with enforceable exclusivity over the specified sGC activator treatment protocol for systemic sclerosis in the United States.

Hutchmed Crystalline Forms Patent Grant US12600713B2

USPTO granted patent US12600713B2 to Hutchmed Limited on April 14, 2026 for crystalline forms of 6-((6,7-dimethoxyquinazolin-4-yl)oxy)-N,2-dimethylbenzofuran-3-carboxamide, a pharmaceutical compound. Inventors are Zhenping Wu, Wenji Li, and Yuping Chu. The patent contains 28 claims and was filed on February 27, 2024.

Hoffmann-La Roche Granted Amino-Pyrimidine Amide Patent US12600712B2

USPTO granted Patent US12600712B2 to Hoffmann-La Roche Inc. on April 14, 2026, covering amino-pyrimidine amide compounds with general formula (I) and methods of using such compounds. The patent includes 11 claims and CPC classifications C07D 403/06 and C07D 491/107 in organic chemistry. The filing date was December 7, 2022, with Application No. 18062644.

Nonpeptide Somatostatin Type 5 Receptor Agonists and Uses Thereof

USPTO granted patent US12600709B2 to Crinetics Pharmaceuticals covering nonpeptide somatostatin type 5 receptor agonists, methods of making the compounds, pharmaceutical compositions, and methods of using the compounds in treating conditions that benefit from somatostatin modulation. The patent includes 4 claims.

MDMA Prodrug Carbamate Compounds - Apoapsis Holdings

USPTO granted Patent US12600708B2 to Apoapsis Holdings, LLC for novel MDMA prodrug carbamate compounds and synthesis methods. The patent covers 19 claims for compounds that are enzymatically cleaved in vivo to produce low-toxicity alcohols. The inventors include Denton W. Hoyer, Robert F. Roscow, Rong Ling, and Chuanjun Gao.

Cannabinoid Derivatives, Precursors and Uses - Patent US12600707B2

USPTO granted patent US12600707B2 to Kare Chemical Technologies Inc. on April 14, 2026, covering new cannabinoid derivatives, precursors, and processes for their preparation. The patent also claims pharmaceutical and analytical uses of these compounds. The patent (10 claims) protects the invention until 2040 based on the September 2020 filing date.

University of Pittsburgh Heat Shock Protein Modulator Patent for Huntington Disease

USPTO granted patent US12600705B2 to University of Pittsburgh for thiadiazine compounds as heat shock protein modulators. The patent covers therapeutic applications for Huntington disease, other neurodegenerative disorders, and cancer. The patent includes 13 claims.

ASKGENE Pharma Granted Patent for Masked Cytokines

USPTO granted Patent No. US12600762B2 to ASKGENE PHARMA, INC. on April 14, 2026. The patent covers masked cytokines (prodrugs) and methods of use for stimulating the immune system, treating cancer, autoimmune diseases, or infectious diseases. The patent contains 19 claims and was filed on January 11, 2021 under Application No. 17787741.

Anti-TDP-43 Binding Molecules and Uses Thereof

The USPTO granted Patent No. US12600766B2 to AC Immune SA covering anti-TDP-43 specific binding molecules, including antibodies and antigen-binding fragments, for diagnosing, preventing, and treating diseases associated with TDP-43 aggregates. The patent lists 15 claims and names Tamara Seredenina, Tamar Magdalena Ziehm, and Tariq Afroz as inventors. The filing date was May 22, 2020, under Application No. 17613444.

Bioniz Therapeutics - Peptide Cytokine Inhibitors Patent Grant US12600757B2

The USPTO granted Patent US12600757B2 to Bioniz Therapeutics, Inc. on April 14, 2026. The patent covers stable peptide antagonists targeting the gamma-c (γc) subunit binding site to inhibit activity of γc-cytokine family members. The 16 claims apply to therapeutic and cosmetic agents as well as research tools for treating diseases associated with γc-family cytokines.

ENZENE BIOSCIENCES - GLP-1 Receptor Agonist Preparation Process Patent

The USPTO granted patent US12600759B2 to Enzene Biosciences Limited covering processes for preparing glucagon-like peptide-1 (GLP-1) receptor agonists and their analogs. The patent specifically encompasses processes for preparing liraglutide, D-liraglutide, semaglutide, and D-semaglutide in substantially pure form. The application (17440127), filed on March 19, 2020, contains 4 claims and covers both solid and solution phase preparation methods.

IBM Granted Patent for Antigen-Binding Proteins Targeting SARS-CoV-2 Variants

USPTO granted IBM (International Business Machines Corporation) Patent US12600764B2 for antigen-binding proteins capable of binding to SARS-CoV-2 coronavirus variants. The patent covers compositions comprising heavy polypeptide chain variable regions with specific amino acid substitutions (R50, I54, L55 positions) that enhance binding to CoV variants. The patent includes 14 claims and was filed on August 27, 2021.

3D-Printed Patient-Specific Surgical Guides Patent Granted to RESTOR3D

USPTO granted patent US12599390B1 to RESTOR3D, Inc. covering 3D-printed patient-specific surgical guides and methods for their production and use. The patent includes 14 claims and covers guides with conformal bone engaging surfaces contoured to patient anatomy, designed to avoid soft tissues during surgical procedures.

Knix Wear Moisture Lock Fluid Retention Garment Patent US12599181B2

USPTO granted Patent US12599181B2 to Knix Wear Inc. on April 14, 2026, covering moisture lock fluid retention assemblies for garments. The patent includes 24 claims protecting technology that uses an absorbent layer and moisture-impermeable layer to retain fluids within the garment assembly. The original application (No. 18419152) was filed on January 22, 2024.

Surgical Forceps and Fixation Thereof

USPTO granted patent US12599395B2 to Gyrus ACMI, Inc. on April 14, 2026, covering a surgical forceps design with an outer shaft, first and second jaws with multiple flanges, and an inner shaft. The invention enables jaw movement between open and closed positions through engagement between the inner shaft and jaw flanges. The patent contains 17 claims and was filed on September 12, 2024 under application number 19108304.

Endoscope Low Light SPSD Image Sensor Patent

USPTO granted patent US12599294B2 to Schölly Fiberoptic GmbH for an image-recording device combining a single photon sensitive detector (SPSD) with a photodiode-based image sensor in an endoscope for improved low-light imaging. The dual-detection approach captures additional spectral information from a common object area to enhance image quality. The patent contains 24 claims and was filed on July 12, 2022.

Bioactive Polypeptides for Plant Protection, Growth and Productivity

USPTO granted Patent US12599649B2 to Spogen Biotech Inc. covering bioactive priming polypeptides for agricultural applications. The patent protects formulations containing 7 claims that enhance plant growth, yield, health, longevity, productivity, and vigor, while reducing abiotic stress and providing protection from disease, insects, and nematodes. The patent was filed on July 20, 2018.

Modified S2 Subunit Coronavirus Spike Protein Patent US12600751B2

The USPTO granted patent US12600751B2 to inventors Annika Kraemer-Kuehl and Thomas Min Stephan for a modified S2 subunit of coronavirus spike protein featuring a mutation at amino acid position 865. The patent covers a recombinant avian coronavirus spike protein or fragment thereof, along with an immunogenic composition containing the modified spike protein. The patent includes 22 claims with filing date May 6, 2020.

Cobra 1/NELF-B as Booster for CD8+ T Cell-Based Therapy - US12600755B2

The USPTO granted Patent US12600755B2 to The George Washington University on April 14, 2026. The patent covers methods of generating T cells with integrated transgenes encoding negative elongation factor (NELF) complex subunits, specifically Cobra 1/NELF-B, for use in treating cancer and infectious disease. The patent contains 19 claims.

RSV Vaccine Methods for Inactivating and Stabilizing Pre-F Protein

USPTO granted patent US12600750B2 to Xiamen University covering methods for inactivating respiratory syncytial virus (RSV) and stabilizing pre-F protein. The patent also covers inactivated RSV virus obtained by the method, vaccines comprising the inactivated virus, and uses of the vaccine for preventing or treating RSV infection. The patent names six inventors including Zizheng Zheng, Wei Zhang, and Ningshao Xia, with 19 claims total.

Native Chemical Ligation Flow Synthesis - University of Sydney

The USPTO granted Patent US12600746B2 to the University of Sydney covering synthetic methods using native chemical ligation in flow for synthesizing polypeptides. The patent, invented by Richard J. Payne and Tim Chisholm, includes 27 claims and covers selective desulfurization or deselenization of amide-containing compounds with thiol, disulfide, selenol, or diselenide functional groups. The patent application was filed on May 22, 2019, under application number 17057069.

Compstatin Analogues Patent for Complement Inhibitors

USPTO granted patent US12600749B2 to ZP SPV 3 K/S on April 14, 2026, covering compstatin analogues with improved complement-inhibiting activity. The patent includes 19 claims for peptide variants with modifications at positions 3 and 9, as well as terminal sequences, providing improved binding affinity and solubility. Inventors include Anne Pernille Tofteng Shelton, Jacob Ulrik Fog, and Jens Kvist Madsen.

Affinity Chromatography of Immunoglobulins Using Pre-capture Flocculation

USPTO granted patent US12600748B2 to RICHTER GEDEON NYRT on April 14, 2026. The patent covers methods for purifying immunoglobulins from cell culture harvest using pre-capture cleaning steps including flocculation and filtration before affinity chromatography. The invention improves eluted immunoglobulin quality, reduces precipitation during chromatography, and extends the lifetime of affinity resin used in large-scale immunoglobulin production.

Methods for Treating Cardiac Valve Disease Using Pharmaceutical Compounds

The USPTO granted Patent US12599608B2 to The Regents of the University of California covering methods of treating cardiac valve disease, including calcific aortic valve disease (CAVD), by administering pharmaceutical compounds of Formulae I-X. The patent names Christina Theodoris and Deepak Srivastava as inventors and includes 4 claims covering therapeutic applications and compound identification methods.

Timolol Compositions for Glaucoma Treatment, Novaliq

USPTO granted patent US12599607B2 to Novaliq GmbH on April 14, 2026, covering pharmaceutical compositions comprising timolol (a β1-receptor blocker) combined with a semifluorinated alkane liquid vehicle for topical ophthalmic administration. The patented compositions are intended for treatment of glaucoma, elevated intraocular pressure, ocular hypertension, and associated symptoms. The patent contains 21 allowed claims.

PDE1 Inhibitors Treat Colon Cancer, USPTO Grant

The USPTO granted Patent US12599603B2 to Intra-Cellular Therapies, Inc. covering phosphodiesterase 1 (PDE1) inhibitors for the treatment of colon cancer and certain tumors. The patent, with inventors Peng Li and Robert Davis, claims 12 method-of-treatment claims. The application was filed on September 3, 2020.

2-AG Enhancing Compositions for Migraine Relief

The USPTO granted Patent US12599600B2 to Arizona Board of Regents on Behalf of the University of Arizona for compositions and methods enhancing 2-arachydonyl glycerol (2AG) activity to prevent and treat headaches, particularly migraines. The patent covers methods for reducing prostaglandin activity and includes claims for pharmaceutical compositions containing 2AG-enhancing compounds.

MEDICON Anti-inflammatory, Anti-cancer, and Anti-angiogenic Compounds Patent

The USPTO granted patent US12599599B2 to MEDICON PHARMACEUTICALS, INC. covering compounds of general Formula A-D-Y with anti-inflammatory, anti-cancer, and anti-angiogenic activity for treating inflammation, cancer, neurodegenerative diseases, and cardiovascular diseases. The patent includes pharmaceutical compositions, methods of making, and methods of use with 4 claims.

Pharmaceutical Compositions with NSAID and Fatty Acid Oxidase Inhibitor for Treating Infections, Inflammation, Aging

The USPTO granted patent US12599614B2 to MD VAULT LLC for pharmaceutical compositions combining non-steroidal anti-inflammatory drugs (NSAIDs) with fatty acid oxidation inhibitors for treating microbial infectious diseases, associated inflammatory disorders, and aging-related conditions. The patent, filed December 13, 2021, contains 9 claims and covers compositions including agents such as diclofenac (A61K 31/616), mefenamic acid (A61K 31/495), and phenylbutazone (A61K 31/192).

Methods of Treating Fuchs Endothelial Corneal Dystrophy After Descemetorhexis

USPTO granted patent US12599609B2 to Kowa Company, Ltd. for methods of treating Fuchs endothelial corneal dystrophy (FECD) following descemetorhexis. The patent covers medications promoting healing in FECD patients and contains 26 claims. The inventors are Gary Gordon and Kazuhito Suehira.

N-Benzhydrylacetamide Inhibitors of Jumanji Domain Histone Demethylases for Cancer Treatment

USPTO granted patent US12599597B2 to the University of Kentucky Research Foundation covering substituted N-benzhydrylacetamide inhibitors of Jumanji domain histone demethylases for treating cancer via Wnt signaling pathway inhibition. The patent includes 10 claims and covers compounds according to Formula I and II, along with methods of administering these compounds to subjects needing cancer treatment.

Vemurafenib Salts for Enteroviral Infection Treatment (US12599591B2)

USPTO granted Patent US12599591B2 to Jyväskylän yliopisto for N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (vemurafenib) and pharmaceutical salts for treating enteroviral diseases. The patent contains 14 claims and is classified under CPC codes A61K 31/437 and A61P 31/16.

Veterinary Formulations Comprising Rapamycin and Methods of Using the Same for Treating Animal Disease

The USPTO granted Patent US12599590B2 to TriviumVet DAC covering veterinary formulations comprising rapamycin or rapalogs for treating animal diseases including cardiac dysfunction, hypertrophic cardiomyopathy, dilated cardiomyopathy, mitral valve disease, cancer, effects of aging, inflammatory disease, and viral infection in companion animals. The patent contains 15 claims and was filed on December 18, 2020.

Succinimide Anticonvulsants Treat Expressive Language Deficit in Autism

USPTO granted patent US12599581B2 to AMS Therapeutics covering a pharmacological method for treating expressive language deficit in autistic humans using succinimide anticonvulsants (ethosuximide, methsuximide, phensuximide). The patent contains 10 claims with application number 18621580 filed on March 29, 2024.

Crystalline Forms of Quinazolinyl-Benzonitrile Compound and Ocular Formulations

USPTO granted patent US12600702B2 to Bausch + Lomb Ireland Limited for crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile and formulations thereof. The patent covers methods for treating ocular surface pain, dry eye disease, and ocular hyperemia. The application was filed on February 13, 2020 under application number 17430819, with 16 claims granted.

N-Acylhydrazonic Compounds Treat Amyloid Diseases, Patent Grant

USPTO granted patent US12600701B2 to Faculdades Católicas for N-acylhydrazonic compounds structurally derived from 1-methyl-1H-imidazole-2-carboxaldehyde for preventing and treating amyloid degenerative aggregopathies including Alzheimer's disease, Parkinson's disease, and type 2 diabetes, as well as non-amyloid conditions such as cataracts. The patent covers four specific compounds and pharmaceutical compositions containing them.

Compositions and Methods for Removal of NMP Degradation Products from NMP Purification Systems

USPTO granted patent US12600697B2 to Refined Technologies, Inc. covering methods for cleaning N-methyl-2-pyrrolidone (NMP) purification and recovery systems. The patent claims compositions and methods using a cleaning solution containing a solvent with a primary amine and hydroxyl group, injected into reflux drums and reboilers, circulated through separation towers to solubilize foulants, then drained. The patent was filed May 25, 2022, and contains 15 claims under CPC classifications C07D 207/267 and C07D 201/16.

Markers, Conjugates, Compositions and Methods for Hypoxia Imaging, Mapping, and Therapy

USPTO granted patent US12600742B2 to WWIKY Biosciences Inc. on April 14, 2026. The patent covers markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy using bio-reductively activated compounds with click chemistry. Inventors include Piyush Kumar, Hassan Elsaidi, Leonard Irving Wiebe, and Michael Weinfeld. The patent includes 5 claims.

Thiosemicarbazates and Uses Thereof - US12600699B2

The USPTO granted Patent US12600699B2 to The Feinstein Institutes for Medical Research covering thiosemicarbazates, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides. The patent also protects a chemoselective functionalization protocol using Mitsunobu reaction for site-specific alkylation. Methods for preparing and using these compounds in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are included in the 17 granted claims.

Kinase Inhibitors Patent - VIDYA Therapeutics, Inc.

USPTO granted Patent US12600698B2 to VIDYA Therapeutics, Inc. on April 14, 2026. The patent covers Bruton tyrosine kinase (BTK) inhibitors designed to penetrate the central nervous system, including pharmaceutical compositions and methods of treatment. The patent includes 21 claims with an August 2022 filing date.

Roche Diagnostics Imidazolium Reagent Mass Spectrometry Patent Grant

The USPTO granted Patent US12600700B2 to Roche Diagnostics Operations, Inc. covering imidazolium compounds and methods for mass spectrometric determination of analyte molecules. The patent, applied for in November 2022 under application number 17991282, was granted with 14 claims. The invention relates to compounds suitable for use in mass spectrometry and associated analytical methods.

Sony Olympus Optical Connector Medical Device Patent Granted

USPTO granted patent US12599290B2 to Sony Olympus Medical Solutions Inc. for an optical connector and medical device. The patent covers an optical connector with an outer frame, collimator lens, and support mechanism for maintaining lens posture using a biasing member and pressing member. The patent includes 11 claims and covers CPC classifications A61B and G02B related to medical optical devices.

AMBU A/S Articulated Endoscope Bending Section Patent

USPTO granted AMBU A/S Patent No. US12599292B2 for an articulated bending section body for an insertion endoscope. The patent covers a design with multiple segments connected by hinge members, where abutment parts are positioned at specific distances from hinges. The patent contains 23 claims and is assigned to AMBU A/S with inventor Kaspar Matthison-Hansen.

Assist Device, Endoscope System, Assist Method and Computer-Readable Recording Medium

USPTO granted patent US12599293B2 to Olympus Corporation on April 14, 2026. The patent covers an assist device and endoscope system that uses fluorescence imaging to estimate the placement period of medical tools within body lumens. The patent contains 13 claims and is classified under CPC subclasses A61B (diagnosis/surgery) and G16H (health informatics).

Capsule Endoscope Graph Component Image Analysis Patent Grant

USPTO granted patent US12599285B2 to Given Imaging Ltd. for a capsule endoscope system that analyzes in-vivo images using connected graph components and machine learning to identify pathology indicators. The patent includes 20 claims covering image processing methods for medical diagnosis.

Endoscopic Camera Arrangement and Method for Camera Alignment Error Correction

The USPTO granted patent US12599288B2 to Erbe Vision GmbH for an endoscopic camera arrangement with camera alignment error correction. The patent addresses augmented reality camera calibration for laparoscopic cameras by using markers within the field of view to determine optical rotation and mechanical misalignment without additional sensors. The patent application was filed October 21, 2022, under application number 17971114, and contains 13 claims.

Power Sources for Wireless Intraoral Scanners

USPTO granted patent US12599286B2 to Align Technology, Inc. covering power source configurations for wireless intraoral scanners. The patent discloses an intraoral scanner with body, probe with scanner head, wireless communication module, optical sensors, and dual power sources including long-distance wireless power transfer receiver or replaceable battery as primary, and rechargeable battery or capacitor as secondary. The patent contains 22 claims.

Endoscope with Raising Base and Biasing Element

USPTO granted Patent US12599289B2 to Olympus Medical Systems Corp. for an endoscope featuring a raising base at the distal end of an insertion portion, a wire mechanism for raising the base, and a biasing element configured to apply biasing force in the raising direction. The patent includes a switching mechanism with two states controlling the wire movement. The patent contains 19 claims.

Self-Locking Endoscope Device Patent B2

USPTO granted patent US12599287B2 to HUNAN VATHIN MEDICAL INSTRUMENT CO., LTD. on April 14, 2026, for a self-locking endoscope device. The patent includes 14 claims and covers a connecting assembly with driven gear and toggle lever, and a fitting assembly with driving gear that engages the driven gear through the toggle lever for self-locking functionality without external force.

ADAMTS-7 Metalloprotease Peptide Vaccine for Anti-Atherosclerosis - Beijing Kimway

The USPTO granted patent US12599654B2 to Beijing Kimway Biotech Co. Ltd. covering immunogenic peptide fragments of metalloprotease ADAMTS-7 and their use in anti-atherosclerosis vaccines. The patent, granted April 14, 2026 with an original filing date of August 20, 2020, includes 3 claims covering short peptide sequences (SEQ ID NO: 1-4) and vaccine compositions designed to inhibit vascular restenosis and atherosclerosis in mouse models.

Serum Albumin-Binding Fibronectin Type III Domains and Therapeutic Applications

USPTO granted Patent US12599652B2 to Janssen Biotech, Inc. covering fibronectin type III (FN3) domains that specifically bind to serum albumin. The patented technology includes related polynucleotides, cells expressing FN3 domains, and FN3 domains fused to heterologous moieties. The invention is designed to extend half-life of molecules in diagnostic and therapeutic applications.

Multivalent Peptide Conjugates for Intra-Articular Joint Inflammation Treatment

USPTO granted patent US12599663B2 to VALITOR, INC. on April 14, 2026. The patent covers multivalent peptide-polymer conjugates designed for sustained intra-articular treatment of joint inflammation, with 23 claims.

Biphenyl Derivative Antimicrobial Adjuvant Patent Granted

USPTO granted Patent US12599575B2 to Korea Research Institute of Bioscience and Biotechnology for an antimicrobial adjuvant containing biphenyl derivative compounds as active ingredients. The patent covers technology that enhances sensitivity of gram-negative bacteria to polymyxin antibiotics, potentially reducing required dosages and associated side effects such as nephrotoxicity. The patent includes 14 claims and was filed on January 28, 2022 under Application No. 18275475.

Indoline Derivatives for Disease Treatment

The USPTO granted patent US12599584B2 to Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. covering indoline derivatives and pharmaceutical compositions for treating diseases associated with oxidative stress, immune response, NO release, and pro-inflammatory cytokines. The patent names Marta Weinstock-Rosin, Abraham Nudelman, and Shani Zeeli as inventors and was filed on January 19, 2017. This grant establishes intellectual property protection for the therapeutic applications of these indoline compounds.

Cenobamate Carbamate Combination Therapy Patent for Epilepsy Treatment

USPTO granted patent US12599585B2 to SK Biopharmaceuticals covering combination therapy using cenobamate [(1R)-1-(2-chlorophenyl)-2-(tetrazol-2-yl)ethyl] carbamate with antiepileptic drugs for preventing or treating neurological disorders such as epilepsy. The patent contains 5 claims and lists inventors Marc Kamin and Laurent Vernillet.

Japan Science and Technology Agency V-ATPase Inhibitor Patent

USPTO granted patent US12599588B2 to Japan Science and Technology Agency for an inhibitor of Na+-translocating V-ATPase activity. The compound serves as an antibacterial agent and medicine with applications in antibacterial and screening methods. The patent application was filed January 15, 2020, contains 12 claims, and covers compounds with specific structural features including hydroxy, alkoxy, and amino substituents on phenyl groups.

Bayer Aktiengesellschaft Substituted Isophthalic Acid Diamides Herbicide Patent, US12599136B2

The USPTO granted Patent US12599136B2 to Bayer Aktiengesellschaft covering substituted isophthalic acid diamides of general formula (I) for use as herbicides. The patent includes 15 claims covering compounds where X and Y are hydrogen, alkyl, or halogen radicals, and Z1 and Z2 are alkyl, cycloalkyl, or phenyl radicals with a heterocyclic Q ring. The patent was filed April 1, 2021, under Application No. 17995662.

Pyrrole Compounds Patent - Aligos Therapeutics - US12599582B2

USPTO granted Patent US12599582B2 to Aligos Therapeutics covering pyrrole compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions, and methods of treating diseases and conditions. The patent names inventors Sandrine Vendeville, David Bernard Smith, Leonid Beigelman, and Vladimir Serebryany. The application was filed August 22, 2023, with 2 claims granted.

Chlorinated Tetralin Compounds and Pharmaceutical Compositions

USPTO granted patent US12599587B2 to Springworks Therapeutics, Inc. on April 14, 2026. The patent covers chlorinated tetralin compounds and pharmaceutical compositions, classified under C07D 233/88 and A61K 31/417. The application (No. 18490993) was filed on October 20, 2023, and the granted patent contains 19 claims.

FDA DMB Acknowledgment Letter to Hyman Phelps McNamara

FDA Division of Manufacturing and Quality (DMB) within CDER sent an acknowledgment letter to Hyman, Phelps & McNamara, P.C. in response to submission FDA-2026-P-4018. The acknowledgment indicates receipt of the submission without substantive review or determination at this stage. No regulatory obligations, compliance deadlines, or enforcement actions are imposed by this document.

Center for Tobacco Products Complaint, Apr 13, 2026

FDA Center for Tobacco Products (CTP) filed a complaint on April 13, 2026. The document is classified as closed in the Regulations.gov system (Docket FDA-2026-H-3804). The full complaint text is not available for public viewing on the regulatory portal. This appears to be a formal complaint related to tobacco product regulation.

BILTRICIDE Not Withdrawn for Safety or Effectiveness

FDA has determined under 21 CFR 314.161 that BILTRICIDE (praziquantel) oral tablet, 600 mg, was not withdrawn from sale for reasons of safety or effectiveness. The drug product, which was discontinued by Bayer Healthcare Pharmaceuticals in February 2024 and moved to the Orange Book's Discontinued Drug Product List, retains its eligibility for ANDA approvals. Novitium Pharma LLC submitted a citizen petition requesting this determination, which FDA granted based on review of Agency records.

FDA Suitability Petition, Comment Period Open

FDA Suitability Petition, Comment Period Open

Suitability Petition to FDA

Hyman, Phelps & McNamara, P.C. filed a Suitability Petition with the FDA under docket FDA-2026-P-4020-0001. The petition appears to request FDA approval for a drug product change under applicable administrative procedures. The filing was submitted to CDER for review.

Robeson County Behavioral Health Urgent Care Ribbon-Cutting Ceremony

North Carolina DHHS announces a ribbon-cutting ceremony for a new Behavioral Health Urgent Care facility in Robeson County on April 17, 2026. NCDHHS provided $2.2 million in funding as part of a historic mental health investment from the North Carolina General Assembly. This is the eighth of a planned 13 new or expanded BHUCs to open statewide.

MDHHS Encourages Syphilis Testing During STI Awareness Week; Cases Up 50%

MDHHS is urging Michigan residents to get tested for syphilis during STI Awareness Week (April 12-18) following a 50% increase in symptomatic and infectious syphilis cases over the past decade. Preliminary 2025 data show rising rates across all populations, including a record 58 congenital syphilis cases in 2024 — the highest in Michigan in over 30 years. The department recommends regular testing, early prenatal care with syphilis screening in the first and third trimesters, and consideration of doxycycline post-exposure prophylaxis (doxy PEP) for exposed individuals.

SC DPH Observes STI Awareness Week, Apr 12-18

SC DPH issued a press release observing National STI Awareness Week (April 12-18). The release presents 2024 data showing 81% of chlamydia cases and 66% of gonorrhea cases in South Carolina were diagnosed in people under 30. Congenital syphilis reached a record high of 44 cases in 2024. The agency emphasized the importance of prenatal care and syphilis screening for pregnant women.

Bed With Foot Warming System Patent Application

USPTO published patent application US20260096666A1 for a bed with integrated foot warming system. The application, filed November 4, 2025, covers a heating unit positioned inside an envelope at the foot of a bed, with power source and electrical connector. Inventors include Kody Lee Karschnik, Omid Sayadi, Wade Daniel Palashewski, Ramazan Demirli, Eric Rose, and Saurabh Chhaparwal.

FDA Reminds 2,200 Sponsors to Disclose Trial Results

The FDA sent messages on March 30, 2026, to more than 2,200 companies and researchers associated with over 3,000 registered clinical trials that do not appear to have submitted required results information to ClinicalTrials.gov. The agency seeks voluntary compliance before considering further regulatory action, including potential Pre-Notices and Notices of Noncompliance.

G47ΔhIL12A Oncolytic HSV for Glioblastoma and Triple-Negative Breast Cancer Treatment

USPTO published patent application US20260097135A1 for G47ΔhIL12A, an oncolytic herpes simplex virus (oHSV) engineered with human IL-12 transgene driven by HCMV IE enhancer/promoter. The invention addresses augmented transgene production and increased virus replication while maintaining safety profiles. Applications include treatment of glioblastoma (GBM) and triple-negative breast cancer (TNBC). Filing date: September 26, 2023; Application No. 19114912.

Controlled Movement Method for Gametes, Zygotes, Embryos

USPTO published patent application US20260098250A1 assigned to CIC nanoGUNE, filed September 6, 2023, covering a method and device for controlled movement of gametes, zygotes, and embryos using micro-scale carriers. The device comprises biocompatible carriers with maximum 500 μm dimensions that can releasably connect to biological cells and move autonomously or via external influences. The technology aims to enable less invasive procedures and higher implantation rates in reproductive medicine and healthcare applications.

Phio Pharmaceuticals T Cell Induction Method for Cancer Treatment

USPTO published patent application US20260097120A1 assigned to Phio Pharmaceuticals Corp. The application covers methods for producing immunogenic compositions using ex vivo T cell treatment with oligonucleotide agents capable of controlling T cell differentiation through PD-1 silencing via chemically modified double-stranded nucleic acid molecules. The disclosed compositions and methods target cancer treatment, including melanoma.

Biallelic Knockout CISH Gene, RNA Compositions

USPTO published patent application US20260097121A1 by inventor Rafi Emmanuel covering RNA compositions with guide sequences targeting the CISH gene for biallelic knockout. The application includes sequences defined by SEQ ID NOs 1-6838 and methods for their use. Filing date was September 18, 2023, under application number 19113098.

Biallelic CIITA Knockout Patent, 34199 RNA Sequences

USPTO published patent application US20260097123A1 for compositions and methods for biallelic CIITA knockout using RNA molecules comprising guide sequences of 17-50 nucleotides. The application covers 34,199 sequences (SEQ ID NOs 1-34199). Inventor: Rafi Emmanuel. Filing date: September 19, 2023.

Patent for RSV vaccine using F protein trimer prefusion conformation

Patent for RSV vaccine using F protein trimer prefusion conformation

Maine LD 2129 Bars Medical Debt Liens and Wage Seizure

Maine Governor Janet Mills signed LD 2129 into law on April 6, 2026, prohibiting medical debt collectors from placing liens on a consumer's principal residence or garnishing wages. The law also bars courts from enforcing wage garnishment orders based on medical debt and prohibits collection of interest on judgments related to liens or attachments on a debtor's principal residence. The legislation expands Maine's prior medical debt protections enacted under LD 558 in June 2025, which barred medical debt reporting to consumer reporting agencies. The law takes effect 90 days after adjournment of the current legislature's second regular session.

Health Care Week in Review: CMS CY 2027 MA Rate Announcement and FY 2027 IPPS/LTCH PPS Proposed Rule

Alston & Bird's weekly health care review summarizing CMS's finalized CY 2027 Medicare Advantage and Part D Rate Announcement and the proposed FY 2027 IPPS and LTCH PPS rule updating Medicare payment policies for inpatient and long-term care hospitals. The review also covers CDC's insufficient evidence finding on WTC Health Program petitions for hepatic steatosis, HHS/ACF's proposed rule to reduce burden for community services programs, and HRSA's funded extension for rural health care provider quality improvement programs.

Regulatory Overview: Post-Approval Changes to Marketed Drugs

Haynes Boone LLP published an overview of FDA reporting requirements for post-approval changes to approved New Drug Applications (NDAs). Drug sponsors must categorize proposed changes as major, moderate, or minor based on potential to affect drug product identity, strength, quality, purity, or potency. Major changes require FDA prior approval before implementation, moderate changes may be implemented 30 days after filing unless FDA objects, and minor changes are reported in annual reports.

Advertising Claim Substantiation Requirements for Health Products

Venable LLP published guidance on FTC and FDA substantiation requirements for health product advertising. The article explains that objective advertising claims for dietary supplements, foods, devices, and cosmetics must be supported by a 'reasonable basis' prior to making the claim. Health-related claims and structure/function claims require competent and reliable scientific evidence, with the specific level of evidence depending on the nature of the claim and what experts in the field would consider appropriate.

Astellas Pharma Inc. v. Ascent Pharms., Inc. — District of Delaware Finds ANDA Infringement of Myrbetriq Patents

A Delaware federal court ruled in favor of Astellas Pharma in patent litigation concerning Myrbetriq (mirabegron extended-release tablets) used to treat overactive bladder. The court found that Ascent Pharmaceuticals' ANDA product infringed all asserted claims of the four patents-in-suit and rejected Ascent's defenses of non-infringement, invalidity based on Section 101 patent eligibility, anticipation, obviousness, and judicial estoppel. The court rejected Ascent's argument that its ANDA product's extended-release characteristics differed meaningfully from Myrbetriq.

Ninth Circuit Finds First Amendment Right to Donate to Patient Assistance Charities, With Possible Impact on Anti-Kickback Statute Enforcement

The Ninth Circuit issued a published decision striking down California Assembly Bill 290 (AB 290) in full on First Amendment grounds, finding that Fresenius and other dialysis clinics have a protected constitutional right to donate to patient assistance charities that engage in expressive activity. The court held that donations driven by commercial self-interest remain constitutionally protected when made to expressive associations like the American Kidney Fund. While the case did not directly involve the federal Anti-Kickback Statute, the decision may call into question the constitutionality of AKS enforcement against pharmaceutical manufacturers making analogous donations.

EPA Draft CCL 6 Lists Microplastics and Pharmaceuticals as Priorities for Drinking Water

EPA issued its draft Sixth Contaminant Candidate List (CCL 6) under the Safe Drinking Water Act on April 6, 2026, marking the first time microplastics and pharmaceuticals have been designated as priority contaminant groups for evaluation. The draft list was published with a public comment period closing June 5, 2026. While CCL listing does not itself impose enforceable limits or obligations on water systems, it signals EPA's research and monitoring priorities for the coming decade.

FDA Launches READI-Home Challenge for Home Medical Devices

FDA Launches READI-Home Challenge for Home Medical Devices

Hilo Wellness Celebration Honors Health Volunteers and Mayors Health Challenge

The Hawaii Department of Health Hawaii District Health Office and the County of Hawaii Mayor's Office invite the public to a wellness celebration on April 24, 2026, from 11 a.m. to 2 p.m. at the Hilo State Building Lanai. The event marks the grand finale of National Public Health Week and National Volunteer Week, honoring health volunteers and continuing the Mayor's Health Challenge Legacy.

Indiana Urges Tick Precautions as Weather Warms

The Indiana Department of Health issued a public health advisory urging Hoosiers to protect themselves from tick bites as warmer weather increases tick activity across the state. The advisory follows the identification of Heartland virus in Indiana ticks and one human case in southern Indiana last year, indicating the presence of a new tick-borne disease in the state. Health officials recommend standard tick prevention measures through late fall.

Solid-State Storage of Biochemical Systems Patent Application

USPTO published patent application US20260098247A1 by inventor Javin Oza disclosing compositions and methods for solid-state storage of biological systems using polymeric cryoprotectants, saccharide cryoprotectants, emulsifiers, and lubricating flow agents, enabling cold chain-free, point-of-care platforms for diagnostics, research, biomanufacturing, and testing.

Novozymes A/S Patent for Enzymatic Plant Protein Extract Method

USPTO published patent application US20260096575A1 assigned to Novozymes A/S for an enzymatic method of producing plant protein extract. The method involves treating plant protein raw materials under alkaline conditions with protein deamidase added before, during, or after treatment, followed by protein recovery and spray drying. The resulting plant protein extract has improved solubility suitable for food or beverage applications. The application was filed on September 28, 2023.

Ultra-High Molecular Weight Xanthan Gum Engineered Strain and Detection Marker

The USPTO published patent application US20260098104A1 for an engineered bacterial strain that produces ultra-high molecular weight xanthan gum with molecular weight exceeding 2.0×10^7 Da, significantly above the ordinary range of 0.2×10^7-2.0×10^7 Da. The application also discloses a molecular marker for detecting the engineered strain and its processed products, enabling rapid identification in production and quality control contexts.

Dura Mater-Derived Stem Cells and Method for Producing the Same

USPTO published patent application US20260098243A1 for dura mater-derived stem cells and production methods. Inventors: Sun Hwa PARK, Sung Won KIM, Seung Ho YANG, Jung Eun LEE, Hyun Ji LEE. The application, filed 2025-10-06 under Application No. 19350367, covers methods of isolating stem cells from dura mater with serum supplements and their use in cell therapeutic agents.

Harvard Patent - Automated Parallel Chromatography for Extracellular Vesicle Purification

USPTO published patent application US20260098244A1 from President and Fellows of Harvard College disclosing devices and methods for automated parallel chromatography for purification of extracellular vesicles from biological samples. The invention includes a pump, computing device, and a stand with columns containing resin and bottom wells or tubes. CPC classifications indicate applications in cell/vesicle technology and chromatography methods.

Stem Cell Differentiation Method for Progenitor Cells and Organoids

The USPTO published patent application US20260098245A1 assigned to Koninklijke Nederlandse Akademie Van Wetenschappen (Royal Netherlands Academy of Arts and Sciences). The application, filed December 10, 2025, covers differentiation methods for progenitor cells including mammalian epithelial stem cells, differentiation media compositions for use in said methods, organoids and cells obtainable by said methods, and therapeutic uses thereof. Inventors are Johannes Carolus Clevers and Helmuth Gehart.

Ureteric Bud Kidney Tissue Engineering Compositions and Methods

The USPTO published patent application US20260098246A1 disclosing engineered ureteric bud kidney tissues and methods for making lumenized kidney tissues with spatially-controlled 3D tubular architecture. The application includes in vitro kidneys comprising nephron progenitor cells and ureteric bud cells. Inventors: Benjamin Shepherd, Alice Chen, J. William Higgins, III. Filed July 30, 2025.

Lipid-Encapsulated Dual-Cleaving Endonuclease for DNA and Gene Editing

USPTO published patent application US20260098248A1 for a lipid-encapsulated dual-cleaving endonuclease enabling non-viral gene editing methods, filed October 10, 2025 under application number 19355897. Inventors include David R. Edgell, Thomas A. McMurrough, Brent E. Stead, and Odisho K. Israel. The invention covers methods of administering a chimeric nuclease to cells or organisms without viral vectors.

Methods for Producing Highly Purified (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate for Enhancing Bodily Function and Treating Disease States

USPTO published patent application US20260098281A1 by Romeo Tango, LLC for methods of producing highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate and biomedical uses thereof. The application covers therapeutic applications including inhibiting inflammasome activation, reducing pro-inflammatory cytokines, improving insulin sensitivity, enhancing mitochondrial biogenesis, and promoting muscle protein synthesis. Additional applications include improving cognitive function, reducing oxidative stress, enhancing cardiovascular health, and supporting neuroprotection.