Pyrrol-2-one compounds for treating gram negative bacterial infections
Summary
The European Patent Office published patent application EP3487496A1 for Unilever IP Holdings B.V. and Unilever Global IP Limited, covering 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one compounds for treating gram negative bacterial infections. The patent was filed with designated states covering all EU member states plus Switzerland, Norway, and other European countries.
What changed
EPO published patent EP3487496A1 granting Unilever intellectual property protection for specific pyrrol-2-one chemical compounds as therapeutic agents against gram negative bacterial infections. The patent application (A1 publication) covers compounds classified under IPC codes A61K 31/4015 and A61K 31/402, with inventors Parry, Pantalone, and Williams. The designated states include all EU member states, Switzerland, Norway, Iceland, and other European countries.
Patent publications do not impose compliance obligations on third parties. Pharmaceutical companies developing similar antibacterial compounds should review this patent to assess potential freedom-to-operate issues. Generic drug manufacturers and researchers in the antimicrobial field should evaluate whether their compounds fall within the scope of the claims before proceeding with development or commercialization activities in designated territories.
Source document (simplified)
4-(4-CHLOROPHENYL)-5-METHYLENE-PYRROL-2-ONE AND 5-METHYLENE-4-(P-TOLYL)PYRROL-2-ONE FOR USE IN THE TREATMENT OF GRAM NEGATIVE BACTERIAL INFECTIONS
Publication EP3487496A1 Kind: A1 Mar 25, 2026
Applicants
Unilever IP Holdings B.V., Unilever Global IP Limited
Inventors
PARRY, Neil, James, PANTALONE, Paolo, WILLIAMS, Paul
IPC Classifications
A61K 31/4015 20060101AFI20180126BHEP A61P 31/00 20060101ALI20180126BHEP A61K 31/402 20060101ALI20180126BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
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