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Pyrrol-2-one compounds for treating gram negative bacterial infections

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Published March 25th, 2026
Detected April 1st, 2026
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Summary

The European Patent Office published patent application EP3487496A1 for Unilever IP Holdings B.V. and Unilever Global IP Limited, covering 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one compounds for treating gram negative bacterial infections. The patent was filed with designated states covering all EU member states plus Switzerland, Norway, and other European countries.

What changed

EPO published patent EP3487496A1 granting Unilever intellectual property protection for specific pyrrol-2-one chemical compounds as therapeutic agents against gram negative bacterial infections. The patent application (A1 publication) covers compounds classified under IPC codes A61K 31/4015 and A61K 31/402, with inventors Parry, Pantalone, and Williams. The designated states include all EU member states, Switzerland, Norway, Iceland, and other European countries.

Patent publications do not impose compliance obligations on third parties. Pharmaceutical companies developing similar antibacterial compounds should review this patent to assess potential freedom-to-operate issues. Generic drug manufacturers and researchers in the antimicrobial field should evaluate whether their compounds fall within the scope of the claims before proceeding with development or commercialization activities in designated territories.

Source document (simplified)

← EPO Patent Bulletin

4-(4-CHLOROPHENYL)-5-METHYLENE-PYRROL-2-ONE AND 5-METHYLENE-4-(P-TOLYL)PYRROL-2-ONE FOR USE IN THE TREATMENT OF GRAM NEGATIVE BACTERIAL INFECTIONS

Publication EP3487496A1 Kind: A1 Mar 25, 2026

Applicants

Unilever IP Holdings B.V., Unilever Global IP Limited

Inventors

PARRY, Neil, James, PANTALONE, Paolo, WILLIAMS, Paul

IPC Classifications

A61K 31/4015 20060101AFI20180126BHEP A61P 31/00 20060101ALI20180126BHEP A61K 31/402 20060101ALI20180126BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

View original document →

Classification

Agency
EPO
Published
March 25th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
EP3487496A1

Who this affects

Applies to
Pharmaceutical companies Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Patent Publication Pharmaceutical Research
Geographic scope
European Union EU

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Healthcare Anti-Money Laundering

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