Oil-in-water emulsions for topical administration with hyaluronan

ChangeBridge: Patent Apps - Pharma (A61K)

Published September 22nd, 2023

Detected March 26th, 2026

Summary

The USPTO has published a patent application (US20260083673A1) for oil-in-water emulsions containing hyaluronan for topical administration. The application details formulations for treating various dermatological conditions, including inflammatory dermatoses, acne, alopecia, and fibrosing pathologies.

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What changed

This document is a publication of a United States patent application (US20260083673A1) filed on September 22, 2023, by inventors associated with the USPTO. The application describes novel oil-in-water Pickering emulsions formulated with hyaluronan and polyester nanoparticles containing therapeutic agents. These emulsions are intended for topical administration and are claimed to be effective in treating a range of conditions, including psoriasis, atopic dermatitis, acne, alopecia, and fibrosing pathologies like keloids.

As this is a patent application publication, it does not impose immediate regulatory obligations or compliance deadlines on regulated entities. However, it signifies potential future developments in pharmaceutical formulations for dermatological treatments. Companies in the pharmaceutical and biotechnology sectors, particularly those involved in topical drug delivery and dermatological therapies, should monitor the progress of this patent application and related intellectual property developments.

Source document (simplified)

← USPTO Patent Applications

OIL-IN-WATER EMULSIONS FOR TOPICAL ADMINISTRATION AND USES THEREOF

Application US20260083673A1 Kind: A1 Mar 26, 2026

Inventors

Laurence MICHEL, Maxime SINTÈS, Claire ALBERT, Florence AGNELY, Mohamed Amine BELADJINE, Nicolas HUANG, Nicolas TSAPIS, Liasmine HAINE HABLAL

Abstract

Oil-in-water Pickering emulsion comprising: an oil phase comprising a first therapeutic agent, an aqueous phase, polyester nanoparticles comprising a second therapeutic agent, wherein the oil phase is in the form of droplets and is dispersed in a continuous aqueous phase, and wherein at least a portion of the nanoparticles are localized at an interface between the oil phase and the aqueous phase, characterized in that the aqueous phase comprises hyaluronan. This new emulsion allows the topical treatment of inflammatory dermatoses such as psoriasis, atopic dermatitis or prurigo, benign skin inflammations such as inflammatory acne, scalp pathologies such asalopecia, dermo-cosmetic conditions, such as very dry irritable skin, tumor pathologies such as mycosis fungoides (indolent cutaneous T lymphoma) or cutaneous mastocytosis (accumulation and abnormal proliferation of mast cells in the dermis, with intense pruritus), and fibrosing pathologies such as keloids (raised, pruritic dystrophic scars, which have the particularity of not regressing spontaneously and of being able to extend beyond the traumatic/injured area).