Severe Liver Injury Warning for Epilepsy Drug Ontozry

Fri, 10 Apr 2026 15:13:22 +0000
Pharmaceuticals

PRAC agreed on a Direct Healthcare Professional Communication for Ontozry (cenobamate) warning of severe liver injury cases with hepatic failure, most occurring when used alongside other anti-seizure medications. The committee recommended adding liver injury as a rare side effect (up to 1 in 1,000) to product information and issued new liver monitoring requirements for prescribers throughout treatment.