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Method for producing maleimide polyethylene glycol derivative

Grant US12595336B2 Kind: B2 Apr 07, 2026

Assignee

NOF CORPORATION

Inventors

Daiki Ozone, Shota Mori, Masaki Ota

Abstract

A method for producing a maleimide polyethylene glycol derivative, may including a reaction step of heating a maleimide polyethylene glycol derivative having a protective group, in a solvent in the presence of silica gel to cause deprotection. A maleimide polyethylene glycol derivative can be produced at a high maleimidization rate while restraining deterioration of a maleimide group on deprotecting the maleimide polyethylene glycol derivative having a protective group.

CPC Classifications

A61K 47/60 C08G 65/33337 C08G 65/33331

Filing Date

2021-12-08

Application No.

18256951

Claims

6