Composition for preventing or treating TNF-α-related disease, comprising hydroflumethiazide as active ingredient
Grant
US12594279B2
Kind: B2
Apr 07, 2026
Assignee
SK CHEMICALS CO., LTD.
Inventors
Soo Min Lee, Jong-In Kim, Nam-Jin Gu, Jeong-Hoon Kim, Dae Hee Han, Hee Jung Koo
Abstract
A composition for preventing or treating a TNF-α-related disease is disclosed. The composition includes hydroflumethiazide or a pharmaceutically acceptable salt thereof as an active ingredient. The composition can effectively inhibit the expression or activity of TNF-α and exhibits an excellent treatment effect compared to methotrexate (MTX) or hydroxychloroquine (HCQ), which are rheumatoid arthritis treatment agents currently on the market, and, thus, can be effectively used for prevention or treatment of a TNF-α-related disease.
CPC Classifications
A61K 31/549
A61K 31/5415
A61P 19/02
A61P 29/00
A61P 19/00
A61P 37/00
A61P 11/00
A61P 3/10
A23L 33/10
A23V 2200/314
A23V 2200/324
A23V 2200/328
A23V 2002/00
Filing Date
2021-11-05
Application No.
18035627
Claims
8