Methods for safe and effective thrombolysis using sequential administration of tissue plasminogen activator and mutant pro-urokinase

Abstract

Provided herein are methods for safe and effective thrombolysis in therapy for human subjects with symptoms of a potential stroke or acute myocardial infarction (“AMI”) using a sequential administration of a low dose bolus of human tissue plasminogen activator (“tPA”) followed by an infusion of a mutant form of human pro-urokinase (“proUK”).

CPC Classifications