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Anti-C-MPL antibody and use thereof

Grant US12590161B2 Kind: B2 Mar 31, 2026

Assignee

DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventors

Kyung Moo Yea, Jee-Yeong Jeong, Sea Gwang Park, Ji Won Shin, Min-Jung Kim

Abstract

The present invention relates to a novel anti-C-MPL antibody and a use thereof, and specifically, to an anti-C-MPL antibody having an effect of increasing platelet production and its number through the maturation of megakaryocytes in the bone marrow, and a use thereof. The novel anti-C-MPL antibody (2R13) of the present invention is a polymer material and has a longer half-life than the conventional therapeutic agents, and it has the advantage of low self-antibody production and low immunogenicity as an antibody agent. In addition, it can be used as a therapeutic agent for thrombocytopenia by increasing the platelet level of patients suffering from chronic or complication-induced immune thrombocytopenia.

CPC Classifications

C07K 16/2866 C07K 2317/21 C07K 2317/52 C07K 2317/622 C07K 2317/70 C07K 2317/75 C07K 2319/00 A61K 39/00 A61K 2039/505 A61P 7/06

Filing Date

2021-11-09

Application No.

18038497

Claims

4