Polymorph of EP4 receptor antagonist, preparation method therefor and use thereof
Grant
US12590103B2
Kind: B2
Mar 31, 2026
Assignee
SHANGHAI YUYAO BIOTECH LTD.
Inventors
Hankun Zhang, Junjie Yang, Mingyao Liu, Wenbo Zhou, Shihong Peng, Huang Chen, Jian Lu
Abstract
Provided are a polymorph of an EP4 receptor antagonist, a preparation method therefor and a use thereof, relating in particular to a polymorph of an EP4 receptor antagonist(S)-4-(1-(2-(4-fluorobenzyl)-4, 7-dihydro-5H-thieno [2,3-c]pyran-3-carboxamido) ethyl) benzoic acid, a preparation method therefor and a use thereof. Compared with an amorphous form of a compound represented by formula I, the polymorph of the present invention has higher stability and better processing performance and is very suitable for being prepared into a medicine.
CPC Classifications
C07D 495/04
C07B 2200/13
A61P 35/00
A61P 37/00
A61P 19/00
Filing Date
2021-01-29
Application No.
17797804
Claims
12