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Polymorph of EP4 receptor antagonist, preparation method therefor and use thereof

Grant US12590103B2 Kind: B2 Mar 31, 2026

Assignee

SHANGHAI YUYAO BIOTECH LTD.

Inventors

Hankun Zhang, Junjie Yang, Mingyao Liu, Wenbo Zhou, Shihong Peng, Huang Chen, Jian Lu

Abstract

Provided are a polymorph of an EP4 receptor antagonist, a preparation method therefor and a use thereof, relating in particular to a polymorph of an EP4 receptor antagonist(S)-4-(1-(2-(4-fluorobenzyl)-4, 7-dihydro-5H-thieno [2,3-c]pyran-3-carboxamido) ethyl) benzoic acid, a preparation method therefor and a use thereof. Compared with an amorphous form of a compound represented by formula I, the polymorph of the present invention has higher stability and better processing performance and is very suitable for being prepared into a medicine.

CPC Classifications

C07D 495/04 C07B 2200/13 A61P 35/00 A61P 37/00 A61P 19/00

Filing Date

2021-01-29

Application No.

17797804

Claims

12