Indolo[2′,3′:3,4]pyrido[2,1-b]quinazoline compound and use thereof
Assignee
INSTITUTE OF MEDICINAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES
Inventors
Shuyi Si, Yanni Xu, Xiao Wang, Jinque Luo, Yongzhen Li, Chao Liu, Xinhai Jiang, Yining Li, Xiaowan Han, Yan Li, Minghua Chen, Jing Zhang, Xin Zhen
Abstract
The disclosure relates to an indolo[2′,3′:3,4]pyrido[2,1-b]quinazoline compound represented by general formula (I) and use thereof in the manufacture of (1) a medicament for treating a cardiovascular and cerebrovascular disease, (2) a formulation for increasing expression of AMPK, ABCA1 and SR-BI, (3) a formulation for activating nuclear receptors (NRs), and inhibiting activity of NLRP3, IL-1β, NF-κB and MAPKs, (4) a formulation for promoting cellular cholesterol efflux; or (5) a medicament for anti-inflammation.
CPC Classifications
Filing Date
2020-09-27
Application No.
17767218
Claims
4