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Levorphanol prodrugs and processes for making and using them

Grant US12590065B2 Kind: B2 Mar 31, 2026

Assignee

Zevra Therapeutics, Inc.

Inventors

Travis Mickle, Sven Guenther, Sanjib Bera

Abstract

The presently described technology provides compositions of one or more of oxoacids, polyethylene glycols, and vitamin compounds chemically conjugated to levorphanol ((−)-17-methylmorphinan-3-ol) to form novel prodrugs and compositions of levorphanol.

CPC Classifications

C07D 215/06 C07D 495/04 C07D 221/28 A61K 31/485 A61K 45/06 A61K 47/542 A61K 47/551 A61K 47/60 A61K 47/64 C07K 5/06026 C07K 5/06052 C07K 5/0806 C07K 5/0808 C07K 5/0812

Filing Date

2018-04-12

Application No.

16604626

Claims

6