Crystalline form of acetylcholinesterase inhibitor and preparation method therefor and application thereof
Assignee
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Inventors
Hong Liu, Yu Zhou, Haiyan Zhang, Yan Fu, Jian Li, Hualiang Jiang, Xican Tang, Kaixian Chen
Abstract
The present invention provides a crystalline form of an acetylcholinesterase inhibitor, a preparation method therefor and application thereof. Specifically, the crystalline form is crystalline form A, crystalline form B and crystalline form C of 2-((1-(2-fluorobenzyl)-4-fluoropiperidin-4-yl) methylene)-5, 6-dimethoxy-2, 3-dihydro-1-indanone. The crystalline form of the present invention does not contain water and solvent, has high stability and low hygroscopicity, is easy to process, and is very suitable for preparing drugs for preventing and/or treating neurodegenerative diseases.
CPC Classifications
Filing Date
2020-11-24
Application No.
17780449
Claims
10