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Crystalline form of acetylcholinesterase inhibitor and preparation method therefor and application thereof

Grant US12590061B2 Kind: B2 Mar 31, 2026

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventors

Hong Liu, Yu Zhou, Haiyan Zhang, Yan Fu, Jian Li, Hualiang Jiang, Xican Tang, Kaixian Chen

Abstract

The present invention provides a crystalline form of an acetylcholinesterase inhibitor, a preparation method therefor and application thereof. Specifically, the crystalline form is crystalline form A, crystalline form B and crystalline form C of 2-((1-(2-fluorobenzyl)-4-fluoropiperidin-4-yl) methylene)-5, 6-dimethoxy-2, 3-dihydro-1-indanone. The crystalline form of the present invention does not contain water and solvent, has high stability and low hygroscopicity, is easy to process, and is very suitable for preparing drugs for preventing and/or treating neurodegenerative diseases.

CPC Classifications

A61P 25/00 A61P 25/28 C07D 211/38 C07B 2200/13

Filing Date

2020-11-24

Application No.

17780449

Claims

10