Haematopoietic stem cell treatment
Grant
US12589115B2
Kind: B2
Mar 31, 2026
Assignee
THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
Inventors
Kamil Romuald Kranc, Dónal O'Carroll
Abstract
The present invention relates to modified haematopoietic stem cells, methods for preparing them, and their use in therapy; as well as methods and reagents for expanding haematopoietic stem cells (HSC) and methods for treating haematological disorders. A particular aspect relates to a method for treating a disease or condition characterised by elevated YTHDF2 expression comprising administering to a patient an effective amount of an YTHDF2 inhibitor. Certain aspects of the invention rely on YTFIDF2 protein level or function and use of YTFIDF2 inhibitors.
CPC Classifications
A61K 31/711
A61K 31/7115
A61K 31/712
C12N 15/11
C12P 19/34
C12Y 207/07
Filing Date
2019-03-29
Application No.
17042008
Claims
7