GABA agonists and antagonists affect differentiation of hematopoietic stem cells and megakaryocyte progenitors
Grant
US12589114B2
Kind: B2
Mar 31, 2026
Assignee
The Board of Trustees of the Leland Stanford Junior University
Inventors
Fangfang Zhu, Irving L. Weissman
Abstract
GABRR1 is shown to be expressed on subsets of hematopoietic stem cells (HSCs) and megakaryocyte progenitors (MkPs). Inhibition of GABRR1 inhibits MkP differentiation and reduction of platelet numbers in blood. Overexpression of GABRR1 or treatment with agonists significantly promotes MkP generation and growth of megakaryocytes.
CPC Classifications
A61K 35/18
A61K 35/19
C07K 14/475
C07K 14/705
C12N 2310/20
C12N 15/1138
C12N 15/907
C12N 2506/11
C12N 2740/16043
Filing Date
2020-05-11
Application No.
17610410
Claims
7