Antibody and chimeric antigen receptor (CAR) binding to CD70, and application thereof
Grant
US12583931B2
Kind: B2
Mar 24, 2026
Assignee
Nanjing IASO Biotechnology Co., Ltd.
Inventors
Yongkun Yang, Guang Hu, Panpan Niu, Guangrong Meng, Jialu Mo, Jianhua Zhang, Qianli Hu, Wei Cheng, Taochao Tan, Qiaoe Wei, Xiangyin Jia, Zhenyu Dai
Abstract
A CD70 antibody and a chimeric antigen receptor (CAR) that can specifically bind to a CD70 protein. The CAR comprises a CD70 binding domain, a transmembrane domain, a costimulatory domain, and an intracellular signaling domain. Further disclosed is an application of the antibody and the CAR for treating diseases or conditions related to CD70 expression.
CPC Classifications
C07K 16/2875
Filing Date
2021-10-12
Application No.
18248771
Claims
18