Compositions and methods for treatment and prevention of Alzheimer's disease
Grant
US12583920B2
Kind: B2
Mar 24, 2026
Assignee
UNIVERSITY OF MARYLAND, BALTIMORE
Inventors
Dudley K. Strickland, Joanna Cooper, Selen M. Catania, Mary M. Migliorini, Brian Hampton, Bradley T. Hyman, Aurelien Lathuiliere
Abstract
The present invention provides methods and compositions for reducing internalization and/or trafficking of tau in neuronal cells comprising contacting the cells with an effective amount of an LRP1 and/or SorLA antagonist. The invention further provides a method of treating or preventing Alzheimer's disease in a subject in need thereof, comprising administering to the subject an effective amount of an LRP1 and/or SorLA antagonist.
CPC Classifications
A61P 25/28
C07K 16/28
C07K 14/705
C07K 2317/76
A61K 38/177
A61K 38/18
Filing Date
2022-04-03
Application No.
17712167
Claims
9