T cell antigen receptor, multimeric complex thereof, and preparation method therefor and use thereof
Grant
US12583910B2
Kind: B2
Mar 24, 2026
Assignee
TSINGHUA UNIVERSITY
Inventors
Lemei Jia, Hua Chen, Wenzhong Li, Jiasheng Wang, Lei Lei, Fang Liu, Xueqiang Zhao, Xin Lin
Abstract
Provided is an antibody or an antigen-binding fragment thereof, a T cell antigen receptor, an immune cell expressing the T cell antigen receptor (TCR), and a preparation method therefor and the use thereof. The TCR can specifically recognize corresponding pMHC complexes, activate TCR T cells, and produce high-level cytokines IFNγ, IL2, TNFα, significantly kill target cells and prolong the life of tumor-bearing mice.
CPC Classifications
C07K 16/085
C07K 2319/03
C07K 14/7051
C07K 14/70539
C07K 2317/565
C07K 2317/622
A61K 40/11
A61K 40/32
A61K 40/42
A61K 40/46
A61K 2239/31
A61K 2239/38
A61K 2239/48
A61K 2039/585
A61K 2039/64
A61K 39/12
A61K 35/17
A61K 2039/5158
C12N 5/0636
C12N 2501/2302
C12N 2502/30
C12N 2510/00
C12N 15/86
C12N 2710/16234
C12N 2740/16043
A01K 2207/12
A01K 2227/105
A01K 2267/0331
A61P 31/20
A61P 31/22
A61P 35/00
G01N 33/56994
G01N 33/574
Filing Date
2021-04-23
Application No.
17923522
Claims
20