DNA-binding domain transactivators and uses thereof
Grant
US12583902B2
Kind: B2
Mar 24, 2026
Assignee
University of Massachusetts
Inventors
Miguel Sena Esteves, Scot A. Wolfe
Abstract
In some aspects, the disclosure relates to recombinant adeno-associated viruses (rAAVs) comprising a nucleic acid encoding a fusion protein comprising a DNA-binding domain and a transcriptional regulator domain and methods of using the same. In some embodiments, expression of the fusion protein results in modified expression of a target gene in a cell.
CPC Classifications
C07K 14/705
C07K 2319/71
C07K 2319/80
C07K 2319/81
C12N 9/22
C12N 15/11
C12N 15/86
C12N 2310/20
C12N 2750/14143
C12N 15/63
C12N 15/113
A61K 38/00
A61K 48/00
A61P 25/08
Filing Date
2020-02-24
Application No.
17433269
Claims
15