PRMT5 inhibitors and uses thereof
Grant
US12583859B2
Kind: B2
Mar 24, 2026
Assignee
California Institute of Technology
Inventors
Brendan M. O'Boyle, Corey M. Reeves, Justin A. Hilf, Brian M. Stoltz, Michael D. Bartberger, Steven J. Wittenberger, Oliver C. Loson, Martina S. McDermott, Neil A. O'Brien, Dennis Slamon
Abstract
The present disclosure describes compounds of formulas (I)-(V) and methods of making the same. The compounds of the present disclosure are useful as inhibitors of PRMT5 activity and in methods of treating cancers and other diseases.
CPC Classifications
C07D 487/04
A61P 35/00
Filing Date
2020-03-25
Application No.
17598152
Claims
24