Interleukin-18 variants and methods of use
Grant
US12582701B2
Kind: B2
Mar 24, 2026
Assignee
Simcha IL-18, Inc.
Inventors
Aaron Ring, Tom Boone
Abstract
The present disclosure provides compositions and methods comprising stabilized IL-18 polypeptides for use in therapeutic and non-therapeutic applications. In some cases, the stabilized IL-18 proteins provide IL-18 signaling activity even in the presence of an inhibitory molecule such as IL-18BP. Also provide are methods of administration and methods for making active polypeptides.
CPC Classifications
A61K 38/20
Filing Date
2023-11-03
Application No.
18501206
Claims
15