Compositions and methods for the treatment of wounds, disorders, and diseases of the skin
Grant
US12582684B2
Kind: B2
Mar 24, 2026
Assignee
Krystal Biotech, Inc.
Inventors
Suma Krishnan, Pooja Agarwal
Abstract
Provided herein are pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. Also provided herein are pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.
CPC Classifications
A61K 35/763
A61K 38/1748
A61K 38/39
A61K 48/005
A61K 9/0014
A61K 9/06
A61K 47/38
A61K 38/443
C07K 14/78
C12N 9/0071
C12N 2710/16643
C12Y 114/11004
A61P 35/00
A61P 17/16
A61P 17/04
A61P 17/02
A61P 17/00
Filing Date
2023-06-27
Application No.
18342284
Claims
18