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Compositions and methods for the treatment of wounds, disorders, and diseases of the skin

Grant US12582684B2 Kind: B2 Mar 24, 2026

Assignee

Krystal Biotech, Inc.

Inventors

Suma Krishnan, Pooja Agarwal

Abstract

Provided herein are pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject. Also provided herein are pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.

CPC Classifications

A61K 35/763 A61K 38/1748 A61K 38/39 A61K 48/005 A61K 9/0014 A61K 9/06 A61K 47/38 A61K 38/443 C07K 14/78 C12N 9/0071 C12N 2710/16643 C12Y 114/11004 A61P 35/00 A61P 17/16 A61P 17/04 A61P 17/02 A61P 17/00

Filing Date

2023-06-27

Application No.

18342284

Claims

18