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Pharmaceutical composition for prevention, amelioration, or treatment of skin disease

Grant US12582680B2 Kind: B2 Mar 24, 2026

Assignee

RIKEN

Inventors

Yoshihiro Ito, Kenya Honda, Masayuki Amagai, Eiryo Kawakami

Abstract

In the present invention, the influence by flora of the skin on dermatitis is examined by analyzing Tmem79-knockout model mice, and a bacterium having a suppressive effect on dermatitis is identified, and the present invention relates to a pharmaceutical composition derived from such a bacterium, containing as active components one or more substances selected from: (a) a bacterial cell of an ampicillin-sensitive bacterium, or a constituent component of the bacterium; (b) a culture supernatant of an ampicillin-sensitive bacterium, or a purified product from the culture supernatant; (c) an extract of an ampicillin-sensitive bacterium; and (d) a metabolite of an ampicillin-sensitive bacterium.

CPC Classifications

A23L 33/135 A23L 33/17 A23L 33/185 A61K 35/747 A61K 35/74 A61P 1/00 A61P 17/00 A61P 17/04 A61P 17/06 C12N 1/205 C12N 1/20 A01K 2217/075 C12R 2001/44 G01N 2800/202 C12Q 1/14

Filing Date

2020-02-03

Application No.

17427988

Claims

3