Cyano-substituted pyridine and cyano-substituted pyrimidine compound and preparation method therefor and application thereof
Grant
US12582654B2
Kind: B2
Mar 24, 2026
Assignee
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
Inventors
Qiang Zhang, Leifu Yang, Nanqiao Zheng, Shannan Yu, Yueming Sun, Zhenke Guo
Abstract
A cyano-substituted pyridine and cyano-substituted pyrimidine compound and a preparation method therefor and an application thereof, which specifically relate to a compound represented by formula (I) and an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt, and a prodrug thereof, and a preparation method therefor and an application thereof in the preparation of a drug as a kinase inhibitor. The compound has good inhibitory activity against kinases such as FGFR4 and mutant FGFR4V550L.
CPC Classifications
A61K 31/506
A61K 31/4545
A61K 31/496
A61K 31/5377
A61K 31/541
C07D 213/84
C07D 239/48
C07D 401/12
C07D 401/14
C07D 405/14
C07D 417/14
Filing Date
2020-12-21
Application No.
17788663
Claims
20