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Chemokine CXCR4 receptor modulators and uses related thereto

Grant US12582645B2 Kind: B2 Mar 24, 2026

Assignee

Emory University

Inventors

Dennis C. Liotta, Edgars Jecs, Robert James Wilson, Huy Hoang Nguyen, Michelle Bora Kim, Lawrence Wilson, Eric Miller, Yesim Altas Tahirovic, Valarie Truax

Abstract

The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.

CPC Classifications

C07D 401/12 C07D 401/14 C07D 405/14 C07D 413/14 C07D 417/12 C07D 417/14 C07D 471/04 C07D 487/04 C07D 487/08 A61P 35/00 A61K 31/4725 A61K 31/496 A61K 31/4985 A61K 31/4995 A61K 31/5377 A61K 31/541

Filing Date

2024-05-03

Application No.

18655194

Claims

27