Compositions and methods for treating cancer with atypical BRAF mutations
Grant
US12582635B2
Kind: B2
Mar 24, 2026
Assignee
Biomed Valley Discoveries, Inc.
Inventors
Gary DeCrescenzo, Dean Welsch, Saurabh Saha
Abstract
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which harbors an atypical BRAF mutation (i.e. a non-V600E/K BRAF mutation), comprising an ERK inhibitor. Also provided are methods for identifying a subject having an atypical BRAF mutant cancer who would benefit from therapy comprising an ERK inhibitor.
CPC Classifications
A61K 33/243
A61K 31/122
A61K 31/131
A61K 31/166
A61K 31/167
A61K 31/175
A61K 31/18
A61K 31/196
A61K 31/198
A61K 31/202
A61K 31/4439
A61P 35/00
Filing Date
2018-05-15
Application No.
16613480
Claims
30