Synthetic methods for preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine
Grant
US12582634B2
Kind: B2
Mar 24, 2026
Assignee
Neurocrine Biosciences, Inc.
Inventors
Andrew Becker, Scott Stirn, Joel Radisson, Christina Marie Costa
Abstract
The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).
CPC Classifications
A61K 31/426
A61K 9/0095
A61K 9/107
A61K 9/28
A61K 9/4833
A61K 45/06
A61K 47/10
A61K 47/14
A61K 47/22
A61K 47/26
A61K 47/32
A61K 31/573
A61K 2300/00
A61K 9/0053
A61K 9/1635
A61K 9/1652
C07D 277/42
C07B 2200/13
A61P 5/00
C07C 209/52
C07C 249/02
C07C 259/06
C07C 211/29
C07C 251/24
G01N 33/74
Filing Date
2020-06-10
Application No.
17782617
Claims
101