Lipid nanoparticle compositions and uses thereof
Grant
US12582611B2
Kind: B2
Mar 24, 2026
Assignee
ReCode Therapeutics, Inc.
Inventors
Mirko Hennig, Ali Ahmed Alfaifi, Sakya Sing Mohapatra, Daniella Ishimaru, Vladimir Grigor'evich Kharitonov, Julia Jung-un Baek, Shuang Li, David J. Lockhart, Brandon A. Wustman, Yufeng Wang, Joseph S. Cefalu
Abstract
Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for cystic fibrosis (CF), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aerosolized pharmaceutical composition to the subject, wherein the LNPs comprise mRNA encoding a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein.
CPC Classifications
A61K 9/12
Filing Date
2024-03-01
Application No.
18593245
Claims
33