IL-15 humanized mouse model and use thereof
Grant
US12582106B2
Kind: B2
Mar 24, 2026
Assignee
GEMPHARMATECH CO., LTD.
Inventors
Cunxiang Ju, Weiwei Yu, Mingkun Zhang, Hongyan Sun, Dingyu Wang
Abstract
Provided are a mouse and a functional activity part thereof, comprising a humanized IL-15 gene; the humanized IL-15 gene comprises a human IL-15 gene segment and a mouse IL-15 gene segment, the human IL-15 gene segment comprises at least a part of exon 4, exon 5, exon 6, exon 7 and exon 8 of the human IL-15 gene, and the mouse IL-15 gene segment comprises exon 1, exon 2 and exon 3 of the mouse IL-15 gene. Also provided are a preparation method and use of the mouse.
CPC Classifications
A01K 67/027
A01K 2217/072
A01K 2217/15
A01K 2227/105
A01K 2267/02
A01K 2267/0368
A01K 67/0275
A61K 49/00
A61K 49/0008
A61P 35/00
C07K 14/54
C07K 14/5443
C12N 15/1136
C12N 2310/20
Filing Date
2020-12-24
Application No.
17764791
Claims
16