Substituted pyrrolo[3,4-b]pyridines as PI3K-α inhibitors
Grant
US12581252B2
Kind: B2
Mar 17, 2026
Assignee
Relay Therapeutics, Inc.
Inventors
Alessandro Boezio, Lucian V. Dipietro, Hakan Gunaydin, Thomas H. McLean, Levi Charles Thomas Pierce, Fabrizio Giordanetto, Yakov Pechersky, Megan Bertrand-Laperle, Alexandre Larivee, Kashif Tanveer, Michael Paul DeNinno, Tarek Mohamed
Abstract
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of formula I-1. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of formula I-1.
CPC Classifications
A61K 31/4035
C07D 209/46
Filing Date
2021-04-29
Application No.
17921580
Claims
20