Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
Grant
US12577590B2
Kind: B2
Mar 17, 2026
Assignee
President and Fellows of Harvard College
Inventors
George M. Church, Kevin M. Esvelt, Prashant G. Mali
Abstract
Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
CPC Classifications
C12N 15/907
C12N 9/22
C12N 15/11
C12N 15/113
C12N 15/85
C12N 2310/3519
C12N 2320/33
C12N 2320/50
C12N 2800/107
C12N 2800/40
C12N 2800/80
C12N 2810/10
C12N 2830/00
C12N 2830/34
C12N 2999/007
C07K 2/00
C12Y 301/00
Filing Date
2023-04-06
Application No.
18296446
Claims
14